Measurement of Circulating Thyrotropin Concentrations by an Immunochemiluminometric Assay
We have developed an immunochemiluminometric assay (ICMA) which has a sensitivity far greater than that of existing immunoassays and which discriminates clearly between euthyroid and hyperthyroid basal TSH levels (1). As part of the clinical validation of this assay, we have measured basal TSH levels in normal and hyperthyroid subjects over a twenty-four hour period. We have also measured the variation in basal TSH levels in a variety of clinically euthyroid patients with acute and chronic non-thyroidal disease.
KeywordsMultinodular Goiter Euthyroid Patient Euthyroid Subject Hyperthyroid Subject Immunochemiluminometric Assay
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