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Measurement of Circulating Thyrotropin Concentrations by an Immunochemiluminometric Assay

  • Peter J. Evans
  • Ian Weeks
  • Stuart Woodhead
  • Keston Jones
  • Reginald Hall
  • Maurice F. Scanlon

Abstract

We have developed an immunochemiluminometric assay (ICMA) which has a sensitivity far greater than that of existing immunoassays and which discriminates clearly between euthyroid and hyperthyroid basal TSH levels (1). As part of the clinical validation of this assay, we have measured basal TSH levels in normal and hyperthyroid subjects over a twenty-four hour period. We have also measured the variation in basal TSH levels in a variety of clinically euthyroid patients with acute and chronic non-thyroidal disease.

Keywords

Multinodular Goiter Euthyroid Patient Euthyroid Subject Hyperthyroid Subject Immunochemiluminometric Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Weeks I, Sturgess M, Siddle K, et al. Clin Endocrinol 20: 489, 1984.CrossRefGoogle Scholar
  2. 2.
    Wehmann RE, Gregerman RI, Burns WH, et al. N Engl J Med 312: 546, 1985.PubMedCrossRefGoogle Scholar
  3. 3.
    Chopra IJ, Van Herle AJ, Teco GNC, et al. J Clin Endocrinol Metab 51: 135, 1980.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Peter J. Evans
    • 1
  • Ian Weeks
    • 1
  • Stuart Woodhead
    • 1
  • Keston Jones
    • 1
  • Reginald Hall
    • 1
  • Maurice F. Scanlon
    • 1
  1. 1.Departments of Medicine and Medical BiochemistryUniversity of Wales College of MedicineCardiff, WalesUK

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