Clinical Experience with a Sensitive Immunoradiometric Assay for Serum Thyrotropin (TSH): Diagnostic and Therapeutic Implications for Hyperthyroid and Thyroid Cancer Patients

  • Monika F. Bayer
  • Joseph P. Kriss
  • I. Ross McDougall


A few patients with subtle signs or symptoms of mild hyperthyroidism, concurrent with consistently normal serum thyroid hormone levels, prompted us to adapt highly sensitive TSH measurements (1–4) to routine clinical use. TSH results in over 300 patients were found to be highly consistent with the clinical impressions and of value in several clinical situations. This account will focus on specific clinical applications, while a more complete report will be published separately (5).


Thyroid Cancer Multinodular Goiter Thyroid Cancer Patient Subtle Sign Serum Thyroid Hormone Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Wehmann RE, Rubenstein HA, and Nisula BC. Endocr Res Commun 6: 249, 1979.PubMedCrossRefGoogle Scholar
  2. 2.
    Spencer CA and Nicoloff JT. Clin Chim Acta 108: 415, 1980.PubMedCrossRefGoogle Scholar
  3. 3.
    Pekary AE, Hershman JM, and Parlow AF. J Clin Endocrinol Metab 41: 676, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    Nisula BC and Louvet JP. J Clin Endocrinol Metab 46: 729, 1978.PubMedCrossRefGoogle Scholar
  5. 5.
    Bayer MF, Kriss JP, and McDougall IR. J Nucl Med (in press).Google Scholar
  6. 6.
    Bayer MF and McDougall IR. Clin Chem 26: 1186, 1980.PubMedGoogle Scholar
  7. 7.
    Pekary AE and Hershman JM. Clin Chem 30: 1213, 1984.PubMedGoogle Scholar
  8. 8.
    Wehmann RE, Rubenstein HA, Pugeat MM, et al. Southern Med J 76: 969, 1983.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Monika F. Bayer
    • 1
  • Joseph P. Kriss
    • 1
  • I. Ross McDougall
    • 1
  1. 1.Nuclear Medicine/RadiologyStanford University School of MedicineStanfordUSA

Personalised recommendations