Ganglioside and Phospholipid Content in Normal and Pathological Human Thyroid
The first step in the action of TSH is the binding of the hormone to a specific receptor in the thyroid plasma membrane (1). Following this event, there is an activation of adenylate cyclase, resulting in increased intracellular cyclic AMP levels (2,3). Cyclic AMP, in turn, interacts with an intracellular target and mediates many of the effects of TSH on the thyroid gland (4). Kohn et al. (5) have recently suggested that gangliosides play an important role in the interaction of TSH with thyroid plasma membrane receptor. Evidence to support this view comes from the demonstration of specific TSH-ganglioside interactions (6), the presence of gangliosides in biologically active systems and their absence in biologically inactive systems (7), and from the reconstitution of a cyclase stimulatory activity by resynthesis of higher order gangliosides in thyroid membranes where a receptor defect has been correlated with a deficiency in higher order gangliosides (8,9).
KeywordsPapillary Carcinoma Human Thyroid Medullary Carcinoma Toxic Adenoma Total Ganglioside
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