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Autoradiographical Portrayal of Distribution Patterns of TSH Receptors in Human Thyroid Gland Tissues

  • Hans-Wilhelm Muller
  • Soren Schroder
  • Gert Wasmus
  • Peter Schmiegelow
  • Bernard Rees Smith

Abstract

The TSH receptor has a central role in the physiological and pathophysiological control of thyroid function. For example, Graves’ disease results from a stimulation of cell metabolism by immunoglobulins binding to the TSH receptor. Recent biochemical studies have been able to establish the subunit structure of the TSH receptor (1,2). However, little is known about the concentration and distribution patterns of TSH receptors in different thyroid tissues. Therefore, we have investigated the possibility of localizing the receptor in tissue sections using 125I-labeled TSH and autoradiography.

Keywords

Focal Nodular Hyperplasia Nodular Goiter Normal Thyroid Tissue Free 125Iodine Toxic Nodular Goiter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Rees Smith B, Rickards CR, Davies Jones E, et al. J Endocrinol Invest 8: 175, 1985.PubMedGoogle Scholar
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    Kajíta Y, Rickards CR, Buckland PR, et al. Biochem J 227: 413, 1985.PubMedGoogle Scholar
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    Schmiegelow P, Lindner J, and Puschmann M. Akt Dermatol 9: 62, 1983.Google Scholar
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    Schultze B. In Handbuch der Allgemeinen Pathologie 1I/5, Springer, Berlin-Heidelberg-New York, 1968, p 466.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Hans-Wilhelm Muller
    • 1
  • Soren Schroder
    • 2
  • Gert Wasmus
    • 1
  • Peter Schmiegelow
    • 2
  • Bernard Rees Smith
    • 3
  1. 1.Department of Nuclear MedicineRadiological ClinicWest Germany
  2. 2.lnstitute of PathologyUniversity of HamburgWest Germany
  3. 3.Endocrine Immunology UnitUniversity of Wales College of Medicine CardiffGreat Britain

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