Autoradiographical Portrayal of Distribution Patterns of TSH Receptors in Human Thyroid Gland Tissues
The TSH receptor has a central role in the physiological and pathophysiological control of thyroid function. For example, Graves’ disease results from a stimulation of cell metabolism by immunoglobulins binding to the TSH receptor. Recent biochemical studies have been able to establish the subunit structure of the TSH receptor (1,2). However, little is known about the concentration and distribution patterns of TSH receptors in different thyroid tissues. Therefore, we have investigated the possibility of localizing the receptor in tissue sections using 125I-labeled TSH and autoradiography.
KeywordsFocal Nodular Hyperplasia Nodular Goiter Normal Thyroid Tissue Free 125Iodine Toxic Nodular Goiter
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