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Isolation and Characterization of the Gene Encoding the ß-Subunit of Rat Thyrotropin

  • Frances E. Carr
  • Laura R. Need
  • Lawrence Shin
  • William W. Chin

Abstract

Thyrotropin (TSH) is a member of the glycoprotein hormone family which includes pituitary lutropin (LH) and follitropin and placental chorionic gonadotropin. As with the other glycoprotein hormones, TSH is composed of two nonconvalently linked subunits, α and TSHβ. The a subunit is common to all of the hormones and the β subunit is distinct for each hormone (1,2). Separate mRNAs which are encoded by separate genes have been identified for the TSH subunits (3–8). In the rat, there appears to be a single TSH mRNA (0.7 Kb) which is consistent with data from Chin et al. (7) that indicates a single rat TSHβ gene. On the other hand, Kourides and co-workers have suggested the possibility of two TSHβ genes in the mouse with only one being expressed (9).

Keywords

Thyroid Hormone Transcriptional Start Site Translational Start Site Glycoprotein Hormone eDNA Probe 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Frances E. Carr
    • 1
    • 2
  • Laura R. Need
    • 1
    • 2
  • Lawrence Shin
    • 1
    • 2
  • William W. Chin
    • 1
    • 2
  1. 1.Section on Molecular GeneticsJoslin Diabetes Center, and Brigham and Women’s HospitalBostonUSA
  2. 2.Howard Hughes Medical InstituteHarvard Medical SchoolBostonUSA

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