Transplacental Antibody-Induced Neonatal Syndromes

  • Margita Zakarija
  • J. Maxwell McKenzie


This review will be divided into the following segments:
  1. 1.

    Overview of what is known regarding the effects on the fetus of the transplacental passage of circulating antibodies that occur in autoimmune thyroid disease.

  2. 2.

    Description of what is known about the progression of development of the fetal thyroid-pituitary axis; relevant comparison will be made of the time frame for fetal and maternal contributions to the concentration of IgG in the fetal circulation.

  3. 3.

    Descriptions, with references to the above reviews, of fetal and neonatal thyroid disorders based on maternal autoimmune thyroid disease, collating published reports with experience garnered in this laboratory.



Autoimmune Thyroid Disease Antithyroid Drug Maternal Antibody Fetal Circulation FRTL5 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Blizzard RM, Chandler RW, Landing HB, et al. N Engl J Med 263: 327, 1960.PubMedCrossRefGoogle Scholar
  2. 2.
    Premachandra BN and Blumenthal HT. J Clin Endocrinol Metab 27: 931, 1967.PubMedCrossRefGoogle Scholar
  3. 3.
    Moroz LA, Meltzer SJ, and Bastomsky CH. J Clin Endocrinol Metab 56: 1009, 1983.PubMedCrossRefGoogle Scholar
  4. 4.
    Lazarus JH, John R, Ginsberg J, et al. Brit Med J 286: 592, 1983.CrossRefGoogle Scholar
  5. 5.
    Czernichow P, Vandalem JL, and Hennen G. J Clin Endocrinol Metab 53: 387, 1981.PubMedCrossRefGoogle Scholar
  6. 6.
    White C. J Obstet Gynaec Brit Emp 21: 231, 1912.CrossRefGoogle Scholar
  7. 7.
    McKenzie JM. J Clin Endocrinol Metab 24: 660, 1964.PubMedCrossRefGoogle Scholar
  8. 8.
    Zakarija M and McKenzie JM. J Clin Endocrinol Metab 57: 1036, 1983.PubMedCrossRefGoogle Scholar
  9. 9.
    Matsuura N, Yamada Y, Nohara Y, et al. N Engl J Med 303: 738, 1980.PubMedCrossRefGoogle Scholar
  10. 10.
    Iseki M, Shimizu M, Oikawa T, et al. J Clin Endocrinol Metab 57: 384, 1983PubMedCrossRefGoogle Scholar
  11. 11.
    Zakarija M, Garcia A, and McKenzie JM. J Clin Invest 76: 1885, 1985.PubMedCrossRefGoogle Scholar
  12. 12.
    Zakarija M, McKenzie JM, and Hoffman WH. J Clin Endocrinol Metab (in press).Google Scholar
  13. 13.
    Van der Gaag RD, Drexhage HA, and Dussault JH. Lancet 1: 246, 1985.PubMedCrossRefGoogle Scholar
  14. 14.
    Fisher DA and Klein AH. N Engl J Med 304: 702, 1981.PubMedCrossRefGoogle Scholar
  15. 15.
    Gitlin D. In BM Kagan and ER Stiehm (eds), Immunologic Incompetence, Year Book Medical Publishers, Inc., Chicago, 1971, p 3.Google Scholar
  16. 16.
    Stites DP. In HH Fudenberg, DP Stites, JL Caldwell, et al. (eds), Basic and Clinical Immunology, Lange Medical Publishers, Los Altos, 1980, p 343.Google Scholar
  17. 17.
    Sutlerland JM, Esselborn VM, Burket RL, et al. N Engl J Med 263: 336, 1960.CrossRefGoogle Scholar
  18. 18.
    Goldsmith RE, McAdams AJ, Larsen PR, et al. J Clin Endocrinol Metab 37: 265, 1973.PubMedCrossRefGoogle Scholar
  19. 19.
    Cove DH and Johnston P. Lancet 1: 430, 1985.PubMedCrossRefGoogle Scholar
  20. 20.
    Volpe R, Ehrlich R, Steiner G, et al. Am J Med 77: 572, 1984.PubMedCrossRefGoogle Scholar
  21. 21.
    Cheron RG, Kaplan MM, Larsen PR, et al. N Engl J Med 304: 525, 1981.PubMedCrossRefGoogle Scholar
  22. 22.
    Zakarija M, McKenzie JM, and Munro DS. J Clin Invest 72: 1352, 1983.PubMedCrossRefGoogle Scholar
  23. 23.
    Drexhage HA, Bottazo GF, Doniach D, et al. Lancet 2: 287, 1980.CrossRefGoogle Scholar
  24. 24.
    Chivato L, Hammond LJ, Hanafusa T, et al. Clin Endocrinol 19: 581, 1983.CrossRefGoogle Scholar
  25. 25.
    Kohn LD, Valente WA, Alvarez FV, et al. In PG Walfish, JR Wall, and R Volpe (eds), Autoimmunity and the Thyroid, Academic Press, Inc., Toronto, 1985, p 217.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Margita Zakarija
    • 1
  • J. Maxwell McKenzie
    • 1
  1. 1.Department of MedicineUniversity of Miami School of MedicineMiamiUSA

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