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Thyroid Hormones and the Developing Brain

  • Gabriella Morreale de Escobar

Abstract

There are three main situations in which an association has been noted between anomalies of thyroid function and mental retardation: (A) Severe endemic goiter associated since the XVIth century with the birth of deaf-mute and imbecile inhabitants, known as cretins (1). This association was recognized before it was even known that goiter is an enlarged thyroid. (B) Congenital hypothyroidism associated with severe mental retardation since Curling described two cases in the mid-XIXth century (2). (C) Maternal hypothyroxinemia, with or without clinical hypothyroidism, associated since the studies of Man et al. (3) with decreased mean I.Q. of the progeny.

Keywords

Thyroid Hormone Iodine Deficiency Congenital Hypothyroidism Embryonic Tissue Spine Distribution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Gabriella Morreale de Escobar
    • 1
  1. 1.Departamento de Endocrinologia Experimental, Instituto de Investigaciones BiomedicasCSIC & Facultad de Medicina UAMMadridSpain

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