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Post-Receptor Events in Growth Control

  • Mario A. Pisarev
  • Gerardo Burton
  • Priscilla Busse Grawitz
  • Gregorio D. Chazenbalk
  • Guillermo J. Juvenal
  • Diana L. Kleiman de Pisarev
  • Leon Krawiec
  • Renata M. Valsecchi

Abstract

TSH regulates thyroid function and growth. However, both clinical observations and experimental results have suggested that TSH is necessary for, but not the trigger of, gland growth. Several findings support this hypothesis:
  1. 1

    Glands with decreased iodine stores are hypersensitive to TSH (1,2).

     
  2. 2

    Serum TSH is normal in some endemic goiter areas (3) and in most thyroid cancers (4,5).

     
  3. 3

    Experimental goiter (LID, MTU, etc.) develops before an increase in serum TSH is detected (6,7).

     
  4. 4

    Goiter size in some endemic areas is inversely related to iodine content (8).

     
  5. 5

    Compensatory thyroid growth, after hemithyroidectomy, may occur in the absence of TSH (9,10).

     

Keywords

Thyroid Cancer Iodine Content Excess Iodine Autoregulatory Mechanism Thyroid Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Mario A. Pisarev
    • 1
  • Gerardo Burton
    • 1
  • Priscilla Busse Grawitz
    • 1
  • Gregorio D. Chazenbalk
    • 1
  • Guillermo J. Juvenal
    • 1
  • Diana L. Kleiman de Pisarev
    • 1
  • Leon Krawiec
    • 1
  • Renata M. Valsecchi
    • 1
  1. 1.Division Bioquimica Nuclear, Comision Nacional de Energia Atomica and Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina

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