Control of Proliferation and of the Expression of Differentiation in Thyroid Cells in Culture
In pluricellular organisms, the biology of individual cells is tightly controlled to follow the constraints and requirements of the organism as a whole. These controls are mostly expressed through extracellular signal molecules (hormones, local hormones, neurotransmitters, etc.). The cellular processes submitted to such controls can be divided into three broad categories: those dealing with the quantitative regulation of function, of growth and proliferation, and the qualitative expression of differentiation. Perversion of the two latter processes leads to tumorigenesis. The study of growth and differentiation expression has mostly used cells in culture as experimental models. In this short review, we wish to report some recent data on the control of dog thyroid cells in primary cultures and compare them to parallel results obtained with other systems and species.
KeywordsEpidermal Growth Factor Cholera Toxin Phorbol Ester Thyroid Cell FRTL Cell
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- 2.Ambesi-Impiombato FS, Picone R, and Tramontano D: In GH Sato, AB Pardee, and DA Sirbasku (eds), Cold Spring Harbor Conferences on Cell Proliferation, Vol. 9, Cold Spring Harbor, 1982, p 483.Google Scholar
- 5.Dumont JE, Roger P, Van Heuverswyn B, et al. Adv Cyclic Nucleotide Res 17: 337, 1984.Google Scholar
- 7.Errick JE, Eggo MC, and Burrow GN: In MC Eggo, and GN Burrow (eds), Progress in Endocrine Research and Therapy, Vol. 2, Raven Press, New York, 1985, p 271.Google Scholar
- 8.Fayet G, and Hovsepian S: In MC Eggo, and GN Burrow (eds), Progress in Endocrine Research and Therapy, Vol. 2, Raven Press, New York, 1985, p 211Google Scholar
- 10.Lamy F, Roger PP, Lecocq R, et al. Eur J Biochem (submitted).Google Scholar
- 17.Roger PP, Reuse S, Servais P, et al. Cancer Res (in press).Google Scholar
- 19.Roger PP, Van Heuverswyn B, Lambert C, et al. Eur J Biochem 1985 (in press).Google Scholar