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Control of Proliferation and of the Expression of Differentiation in Thyroid Cells in Culture

  • Jacques E. Dumont
  • Pierre P. Roger
  • Patricia Servais
  • Catherine Gerard
  • Sylvia Reuse
  • Anne Lefort
  • Raymond Lecocq
  • Francoise Lamy

Abstract

In pluricellular organisms, the biology of individual cells is tightly controlled to follow the constraints and requirements of the organism as a whole. These controls are mostly expressed through extracellular signal molecules (hormones, local hormones, neurotransmitters, etc.). The cellular processes submitted to such controls can be divided into three broad categories: those dealing with the quantitative regulation of function, of growth and proliferation, and the qualitative expression of differentiation. Perversion of the two latter processes leads to tumorigenesis. The study of growth and differentiation expression has mostly used cells in culture as experimental models. In this short review, we wish to report some recent data on the control of dog thyroid cells in primary cultures and compare them to parallel results obtained with other systems and species.

Keywords

Epidermal Growth Factor Cholera Toxin Phorbol Ester Thyroid Cell FRTL Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jacques E. Dumont
    • 1
  • Pierre P. Roger
    • 1
  • Patricia Servais
    • 1
  • Catherine Gerard
    • 1
  • Sylvia Reuse
    • 1
  • Anne Lefort
    • 1
  • Raymond Lecocq
    • 1
  • Francoise Lamy
    • 1
  1. 1.Institute of Interdisciplinary Research, School of MedicineUniversity of Brussels and Biology Department, EuratomBrusselsBelgium

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