Inhibition of T4 5’-Deiodinase in Human Placental Cells by Cyclic-AMP, Butyrate, and Calcium

  • Jairo T. Hidal
  • Michael M. Kaplan


Conversion of T4 to T3 (T4 5’-deiodination) by human placental cells (1–3), which occurs via the type II iodothyronine pathway (4), is inhibited by physiological concentrations of iodothyronines in the potency order T4 = rT3 > T3 (3). Type II deiodination is responsible for much of the tissue T3 content in the rat brain and anterior pituitary gland (5), and may, under some circumstances, contribute significantly to the circulating T3 pool in both rats and humans (5,6). Since type II T4 5’-deiodination could thus constitute an important step in the expression of thyroid hormone effects, we wished to obtain a more complete understanding of the regulation of this process in a human system.


Placental Alkaline Phosphatase Deiodinase Activity Research Career Development Award Thyroid Hormone Effect Human Placental Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Banovac K, Bzik L, Tislaric D, et al. Horm Res 12: 253, 1980.PubMedCrossRefGoogle Scholar
  2. 2.
    Kaplan MM and Shaw EA. J Clin Endocrinol Metab 59: 253, 1984.PubMedCrossRefGoogle Scholar
  3. 3.
    Hidal JT and Kaplan MM. J Clin Invest 76: (in press), 1985.Google Scholar
  4. 4.
    Kaplan MM. Neuroendocrinology 38: 254, 1984.PubMedCrossRefGoogle Scholar
  5. 5.
    Silva JE and Matthews P. Endocrinology 115: 2394, 1984.CrossRefGoogle Scholar
  6. 6.
    Lum SMC, Nicoloff JT, Spencer CA, et al. J Clin Invest 73: 570, 1984.PubMedCrossRefGoogle Scholar
  7. 7.
    Bradford M. Analyt Biochem 72: 248, 1976.PubMedCrossRefGoogle Scholar
  8. 8.
    Leonard JL and Gogolin PJ. Ann d’endocrinologie 45: 61, 1984.Google Scholar
  9. 9.
    Ito F and Chou JY. J Biol Chem 259: 2526, 1984.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jairo T. Hidal
    • 1
    • 2
  • Michael M. Kaplan
    • 1
    • 2
  1. 1.Thyroid Diagnostic CenterBrigham and Women’s Hospital Harvard Medical SchoolBostonUSA
  2. 2.Endocrinology DivisionNew England Medical Center Hospital, Tufts University School of MedicineBostonUSA

Personalised recommendations