Conversion of T4 to T3 (T4 5’-deiodination) by human placental cells (1–3), which occurs via the type II iodothyronine pathway (4), is inhibited by physiological concentrations of iodothyronines in the potency order T4 = rT3 > T3 (3). Type II deiodination is responsible for much of the tissue T3 content in the rat brain and anterior pituitary gland (5), and may, under some circumstances, contribute significantly to the circulating T3 pool in both rats and humans (5,6). Since type II T4 5’-deiodination could thus constitute an important step in the expression of thyroid hormone effects, we wished to obtain a more complete understanding of the regulation of this process in a human system.
Placental Alkaline Phosphatase Deiodinase Activity Research Career Development Award Thyroid Hormone Effect Human Placental Cell
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