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Inherited Disorders of Thyroid Hormone Action

  • Jack Gross

Abstract

Disorders of thyroid hormone action have only been characterized by resistance to thyroid hormone (THR). This is manifest by a normal or high circulating level of thyroid hormones with an inappropriate response of the target tissues, either in terms of metabolic activity and/or TSH secretion. There are a number of comprehensive reviews (1,2) that have dealt with the subject up to 1981. I have reviewed the literature to date to try and obtain further insight into the types, frequencies, and underlying mechanisms of these disorders. Because of the small number of cases reported, I have included sporadic, as well as inherited cases. I will also mention two animal models of inherited thyroid hormone resistance.

Keywords

Thyroid Hormone Thyroid Hormone Action Deiodinase Activity Hypothyroid Group Nephropathic CYSTINOSIS 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jack Gross
    • 1
  1. 1.The Hubert H. Humphrey Center for Experimental Medicine and Cancer ResearchThe Hebrew University — Hadassah Medical SchoolJerusalemIsrael

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