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Characteristics of T4 Inner Ring Deiodinase in the Liver, Kidney, and Cerebral Cortex of Rat: Two Kinds of Isoenzymes

  • Yasunori Ozawa
  • Yoshimasa Shishiba
  • Itsuko Kinami

Abstract

The major pathway of the peripheral metabolism of thyroid hormone is serial deiodination by enzymes. The first step of the deiodination of thyroxine is the removal of iodine at 5 or 5’ position, and these two activities are known to be comparable in in vivo kinetics studies.

Keywords

Cerebral Cortex Microsomal Fraction Peripheral Metabolism Toranomon Hospital Radation Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Visser TJ, Leonard JL, Kaplan MM, et al. Proc Nat Acad Sci USA 79: 5080, 1982.PubMedCrossRefGoogle Scholar
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    Silva JE, Leonard JL, Crantz FR, et al. J Clin Invest 69: 1176, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Kaplan MM and Utiger RD. J Clin Invest 61: 459, 1978.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Yasunori Ozawa
    • 1
  • Yoshimasa Shishiba
    • 1
  • Itsuko Kinami
    • 1
  1. 1.Division of Endocrinology, Toranomon Hospital and OkinakaMemorial Institute for Medical ResearchToranomon, Minatoku, TokyoJapan

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