Effect of Thyroid Hormones, Food Deprivation, and Cold Exposure on Thyroid T4 Outer Ring Monodeiodinating Activity (5’MDI) in Mice
Active iodothyronine inner-ring and outer-ring monodeiodinases (5 and 5’MDI) are present in thyroid (1–3). The evidence suggests they are maintained and can be stimulated by TSH (3,4). More recently, we have shown that they are extremely sensitive to TSH stimulation and the increase is dose-dependent (5). Furthermore, we have demonstrated that LATS-rich patient serum stimulates T4 5’MDI in mouse thyroid (6), and appears to correlate well with the kinetic data (7,8) which suggest a preferential secretion of T3 from thyroid in hyperthyroid patients. The present studies examine the effect of thyroid hormones, starvation, and cold on thyroid 5’MDI in comparison with those in liver, kidney, or brown adipose tissue (BAT).
KeywordsThyroid Hormone Brown Adipose Tissue Cold Exposure Pharmacological Dose Hyperthyroid Patient
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