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Thyroid Hormone-Binding Plasma Proteins

  • Chapter
Frontiers in Thyroidology

Abstract

The thyroid hormones thyroxine (T4) and 3,3′,5-triiodothyronine (T3) are bound to serum proteins for more than 99%. These proteins are thyroxine-binding protein (TBG), thyroxine-binding prealbumin (TBPA), and albumin. TBG is the most important T4 transport protein as it binds about 75 to 80% of T4, while both TBPA and albumin bind approximately 10% (1). There is no unanimity in the literature with regard to the exact serum distribution of T3 over the serum proteins, however probably also here TBG binds most of it (2). In this short review some physico-chemical characteristics of these proteins will be discussed, as well as their interaction with T4 and T3 and in the case of TBPA also its interaction with retinol-binding protein. In addition, the genetic aspects will be reviewed.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine III, Rotterdam, The Netherlands

    Georg Hennemann, Eric P. Krenning & Roelof Docter

  2. Department of Nuclear Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands

    Eric P. Krenning

Authors
  1. Georg Hennemann
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  2. Eric P. Krenning
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  3. Roelof Docter
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Editor information

Editors and Affiliations

  1. University of São Paulo Medical School, São Paulo, Brazil

    Geraldo Medeiros-Neto M.D. (Professor of Medicine, Secretary General) (Professor of Medicine, Secretary General)

  2. Ninth International Thyroid Congress, São Paulo, Brazil

    Geraldo Medeiros-Neto M.D. (Professor of Medicine, Secretary General) (Professor of Medicine, Secretary General)

  3. University of Mississippi Medical School, Jackson, Mississippi, USA

    Eduardo Gaitan M.D. (Professor of Medicine, Chief) (Professor of Medicine, Chief)

  4. Endocrinology Section, Veterans Administration Medical Center, Jackson, Mississippi, USA

    Eduardo Gaitan M.D. (Professor of Medicine, Chief) (Professor of Medicine, Chief)

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© 1986 Springer Science+Business Media New York

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Hennemann, G., Krenning, E.P., Docter, R. (1986). Thyroid Hormone-Binding Plasma Proteins. In: Medeiros-Neto, G., Gaitan, E. (eds) Frontiers in Thyroidology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5260-0_14

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  • DOI: https://doi.org/10.1007/978-1-4684-5260-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5262-4

  • Online ISBN: 978-1-4684-5260-0

  • eBook Packages: Springer Book Archive

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