Ontogeny of Nuclear T3 Receptor in Primary Cultured Astrocytes

  • Min Luo
  • Robert Faure
  • Jean H. Dussault


Thyroid hormones play an essential role in assuring normal development and optimal function of the mammalian brain (1–3). It is generally admitted that most of the physiological action of T3 is mediated by its interaction with a specific nuclear receptor (NTR) (4). Ontogenesis of T3 receptor in the developing rat brain is well documented (5,6). However, few data are available about its distribution in specific cell types. Previous work in our laboratory has shown that in the central nervous system of adult rats, the NTR is located in neuronal cells and absent in glial cells (7). Since no astrocytes were present in our preparations, we further investigate in vitro the localization of the receptor in this cell line.


Thyroid Hormone Relative Binding American Thyroid Association Relative Binding Affinity Primary Cultured Astrocyte 
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  1. 1.
    Grave GD. Thyroid Hormones and Brain Development, Raven Press, New York, 1977.Google Scholar
  2. 2.
    Legrand J. J Physiol 78: 603, 1982–83.Google Scholar
  3. 3.
    Sokoloff L and Kennedy L. In GE Gaul (ed), Biology of Brain Dysfunction, Plenum Press, New York, 1973, p 295.CrossRefGoogle Scholar
  4. 4.
    Oppenheimer JH. Ann Intern Med 102: 374, 1985.PubMedCrossRefGoogle Scholar
  5. 5.
    Schwartz HL and Oppenheimer JH. Endocrinology 103: 943, 1978.PubMedCrossRefGoogle Scholar
  6. 6.
    Valcana T and Timiras PS. Mol Cell Endocrinol 11: 31, 1978.PubMedCrossRefGoogle Scholar
  7. 7.
    Ruel J, Faure R, and Dussault JH. American Thyroid Association (1982) and J Endocrinol Invest (in press).Google Scholar
  8. 8.
    Schousboe A, Fosmark H, and Formby B. J Neurochem 26: 1053, 1976.CrossRefGoogle Scholar
  9. 9.
    Bernal J, Coleoni AM, and DeGroot LJ. Endocrinology 103: 403, 1978.PubMedCrossRefGoogle Scholar
  10. 10.
    Hansson E. Neurochem Res 9: 153, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Min Luo
    • 1
  • Robert Faure
    • 1
  • Jean H. Dussault
    • 1
  1. 1.Unite d’Ontogenese et Genetique Moleculaire Le Centre Hospitalierl’Universite LavalSainte-FoyCanada

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