Ontogeny of Nuclear T3 Receptor in Primary Cultured Astrocytes
Thyroid hormones play an essential role in assuring normal development and optimal function of the mammalian brain (1–3). It is generally admitted that most of the physiological action of T3 is mediated by its interaction with a specific nuclear receptor (NTR) (4). Ontogenesis of T3 receptor in the developing rat brain is well documented (5,6). However, few data are available about its distribution in specific cell types. Previous work in our laboratory has shown that in the central nervous system of adult rats, the NTR is located in neuronal cells and absent in glial cells (7). Since no astrocytes were present in our preparations, we further investigate in vitro the localization of the receptor in this cell line.
KeywordsThyroid Hormone Relative Binding American Thyroid Association Relative Binding Affinity Primary Cultured Astrocyte
Unable to display preview. Download preview PDF.