Induction of Liver Mitochondrial α-Glycerophosphate Dehydrogenase (α-GPD) by Glucocorticoid Deficit: Role of the Nuclear T3-Receptor (nT3-R)
It was reported that adrenalectomy in rats induced an increase in mitochondrial α-glycerophosphate dehydrogenase activity (α-GPD) although the mechanism of this activation was not elucidated (1). More recently, we found that the increase in α-GPD activity under a glucocorticoid deficit was accompanied by an increase in the affinity of liver nT3-R (2). This paper explores further the mechanism involved in the activation of α-GPD under a glucocorticoid deficit. We also attempted to establish a relationship between the changes in the affinity of nT3-R and the activity of this T3-dependent enzyme.
KeywordsSucrose MgCl2 CaCl2 Dexamethasone Glucocorticoid
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