Induction of Liver Mitochondrial α-Glycerophosphate Dehydrogenase (α-GPD) by Glucocorticoid Deficit: Role of the Nuclear T₃-Receptor (nT₃-R)

Abstract

It was reported that adrenalectomy in rats induced an increase in mitochondrial α-glycerophosphate dehydrogenase activity (α-GPD) although the mechanism of this activation was not elucidated (1). More recently, we found that the increase in α-GPD activity under a glucocorticoid deficit was accompanied by an increase in the affinity of liver nT₃-R (2). This paper explores further the mechanism involved in the activation of α-GPD under a glucocorticoid deficit. We also attempted to establish a relationship between the changes in the affinity of nT₃-R and the activity of this T₃-dependent enzyme.

Supported by a grant from CONICET (Argentina).