Direct Thyroid Hormone Stimulation of Mitochondrial Oxidative Phosphorylation: The Role of Adenine Nucleotide Translocase (AdNT)
Since the first reports 30 years ago of direct thyroid hormone action on target cell mitochondria (1–3), Bronk observed that the oxidative capacity of rat liver mitochondria was markedly reduced by thyroidectomy, and substantially restored within three hours after triiodothyronine (T3) injection in studies on the electron transport system (4,5) with no change whatever in coupling of oxidative phosphorylation; that is, phosphorus/ oxygen (P/0) ratios remained constant.
KeywordsThyroid Hormone Thyroid Hormone Stimulation Liver Mitochondrion Scatchard Plot Adenine Nucleotide Translocase
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