Abstract
Since the first reports 30 years ago of direct thyroid hormone action on target cell mitochondria (1–3), Bronk observed that the oxidative capacity of rat liver mitochondria was markedly reduced by thyroidectomy, and substantially restored within three hours after triiodothyronine (T3) injection in studies on the electron transport system (4,5) with no change whatever in coupling of oxidative phosphorylation; that is, phosphorus/ oxygen (P/0) ratios remained constant.
Supported by the Veterans Administration Research Service, Grant PCM8100280 from the National Science Foundation, and grants from the Kroc Foundation for Medical Research, and the Burroughs Wellcome Fund.
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References
Martius C and Hess B. Arch Biochem Biophys 33: 486, 1951.
Hock FL and Lipmann F. Proc Natl Acad Sci USA 40: 909, 1954.
Tapley DF, Cooper C, and Lehninger AL. Biochim Biophys Acta 19: 507, 1955.
Bronk JR. Science 153: 638, 1966.
Bronk JR and Bronk MS. J Biol Chem 237: 897, 1962.
Sterling K, Brenner MA, and Sakurada T. Science 210: 340, 1980.
Sterling K and Milch PO. Proc Natl Acad Sci USA 72: 3225, 1975.
Goglia F, Torresani J, Bugli P, et al. Pflugers Arch 390: 120, 1981.
Hashizume K and Ichikawa K. Biochem Biophys Res Comm 106: 920, 1982.
Sterling K, Lazarus JH, Milch PO, et al. Science 201: 1126, 1978.
Barker SB and Klitgaard HM. Am J Physiol 170: 81, 1952.
Sterling K, Campbell G, and Brenner MA. Acta Endocrinol 105: 391, 1984.
Aquila H, Misra D, Eulitz M, et al. Hoppe-Seyler’s Z Physiol Chem 363: 345, 1982.
Babior BM, Creagan S, Ingbar SB, et al. Proc Natl Acad Sci USA 70: 98, 1973.
Portnay GI, McClendon DD, Bush JE, et al. Biochem Biophys Res Comm 55: 17, 1973.
Verhoeven AJ, Kamer P, Groen AK, et al. Biochem J 226: 183, 1985.
Seitz HJ, Muller MJ, and Sobell S. Biochem J 227: 149, 1985.
Mowbray J and Corrigall J. Eur J Biochem 139: 95, 1984.
Klingenberg M, Riccio P, and Aquila H. Biochim Biophys Acta 503: 193, 1978.
Woldegiorgis G, Yousufzai SYK, and Shrago E. J Biol Chem 257: 14783, 1982
Sterling K, Campbell GA, and Brenner MA. Trans Assoc Amer Phys 96: 324, 1983.
van der Walt B, Nikodem VM, and Cahnmann HJ. Proc Natl Acad Sci USA 79: 3508, 1982.
Laemmli UK. Nature (London) 227: 680, 1970.
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Sterling, K. (1986). Direct Thyroid Hormone Stimulation of Mitochondrial Oxidative Phosphorylation: The Role of Adenine Nucleotide Translocase (AdNT). In: Medeiros-Neto, G., Gaitan, E. (eds) Frontiers in Thyroidology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5260-0_133
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DOI: https://doi.org/10.1007/978-1-4684-5260-0_133
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