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Direct Thyroid Hormone Stimulation of Mitochondrial Oxidative Phosphorylation: The Role of Adenine Nucleotide Translocase (AdNT)

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Abstract

Since the first reports 30 years ago of direct thyroid hormone action on target cell mitochondria (1–3), Bronk observed that the oxidative capacity of rat liver mitochondria was markedly reduced by thyroidectomy, and substantially restored within three hours after triiodothyronine (T3) injection in studies on the electron transport system (4,5) with no change whatever in coupling of oxidative phosphorylation; that is, phosphorus/ oxygen (P/0) ratios remained constant.

Supported by the Veterans Administration Research Service, Grant PCM8100280 from the National Science Foundation, and grants from the Kroc Foundation for Medical Research, and the Burroughs Wellcome Fund.

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Author information

Authors and Affiliations

  1. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA

    Kenneth Sterling

  2. The VA Medical Center, Bronx, NY, USA

    Kenneth Sterling

Authors
  1. Kenneth Sterling
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Editor information

Editors and Affiliations

  1. University of São Paulo Medical School, São Paulo, Brazil

    Geraldo Medeiros-Neto M.D. (Professor of Medicine, Secretary General) (Professor of Medicine, Secretary General)

  2. Ninth International Thyroid Congress, São Paulo, Brazil

    Geraldo Medeiros-Neto M.D. (Professor of Medicine, Secretary General) (Professor of Medicine, Secretary General)

  3. University of Mississippi Medical School, Jackson, Mississippi, USA

    Eduardo Gaitan M.D. (Professor of Medicine, Chief) (Professor of Medicine, Chief)

  4. Endocrinology Section, Veterans Administration Medical Center, Jackson, Mississippi, USA

    Eduardo Gaitan M.D. (Professor of Medicine, Chief) (Professor of Medicine, Chief)

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© 1986 Springer Science+Business Media New York

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Sterling, K. (1986). Direct Thyroid Hormone Stimulation of Mitochondrial Oxidative Phosphorylation: The Role of Adenine Nucleotide Translocase (AdNT). In: Medeiros-Neto, G., Gaitan, E. (eds) Frontiers in Thyroidology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5260-0_133

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  • DOI: https://doi.org/10.1007/978-1-4684-5260-0_133

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5262-4

  • Online ISBN: 978-1-4684-5260-0

  • eBook Packages: Springer Book Archive

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