Evidence for Nuclear T3 Receptors in Neonatal Cerebral Astrocytes

  • Carlos C. Callegari
  • Ronald H. Tarris
  • Stephen Cheung
  • Morton E. WeichselJr.
  • Delbert A. Fisher


An important effect of thyroid hormones on brain development has been well documented (1) and T4 nuclear receptors have been described in whole brain of several animal species (2–5). In developing chick brain, T3 nuclear receptors are distributed in both neurons and glial cells (6). We have shown that astrocytes from 2 and 12 day old mice in culture produce Nerve Growth Factor (NGF) (7) and that brain NGF concentrations in the developing mouse are thyroid hormone responsive (8). This data suggested that astrocytes may have T3 receptors. However, recent studies, in abstract form, report the absence of T3 receptors in 17 day fetal rat brain glial cells (9). No data are currently available regarding T3 receptors in astrocytes of developing rodent brain. Therefore, the present study was conducted to characterize the T3 receptor in mouse neonatal astrocytes.


Thyroid Hormone Nerve Growth Factor Mouse Astrocyte Brain Astrocyte Maximal Binding Capacity 
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  1. 1.
    Grave GD. Thyroid Hormones and Brain Development, Raven Press, New York, 1977.Google Scholar
  2. 2.
    Oppenheimer HJ, Schwartz HL, and Surks MI. Endocrinology 95: 897, 1974.PubMedCrossRefGoogle Scholar
  3. 3.
    Bellabarba D, Bedard S, Fortier S, et al. Endocrinology 112: 353, 1983.PubMedCrossRefGoogle Scholar
  4. 4.
    Schwartz HL and Oppenheimer JH. Endocrinology 103: 943, 1978.PubMedCrossRefGoogle Scholar
  5. 5.
    Bernal J and Pekonen F. Endocrinology 114: 677, 1984.PubMedCrossRefGoogle Scholar
  6. 6.
    Haidar MA, Dube S, and Sarkar PK. Biochem Biophys Res Commun 112: 221, 1983.PubMedCrossRefGoogle Scholar
  7. 7.
    Tarris R, Weichsel Jr ME, et al. Submitted.Google Scholar
  8. 8.
    Walker P, Weil ML. Weichsel Jr ME, et al. Life Sciences 28: 1977, 1981.CrossRefGoogle Scholar
  9. 9.
    Kolodny JM, Leonard JL, and Larsen PR. Program of LX Meeting American Thyroid Association, T2, Sept. 1984.Google Scholar
  10. 10.
    Bernal J, Coleoni AH, and DeGroot L. Endocrinology 103: 403, 1978.PubMedCrossRefGoogle Scholar
  11. 11.
    Scatchard G. Ann NY Acad Sci 51: 660, 1949.CrossRefGoogle Scholar
  12. 12.
    Hill BT and Whatley S. FEES Lett 56: 1975.Google Scholar
  13. 13.
    Lowry OH, Rosebrough NJ, Farr AL, et al. J Biol Chem 252: 6799, 1951.Google Scholar
  14. 14.
    Sokoloff L and Kennedy C. In GE Gaull (ed), Biology of Brain Dysfunc-tion, Vol. 2, Plenum Press, New York, 1973, p 295.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Carlos C. Callegari
    • 1
  • Ronald H. Tarris
    • 1
  • Stephen Cheung
    • 1
  • Morton E. WeichselJr.
    • 1
  • Delbert A. Fisher
    • 1
  1. 1.Department of PediatricsHarbor-UCLA Medical Center, UCLA School of MedicineTorranceUSA

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