Evidence for Nuclear T3 Receptors in Neonatal Cerebral Astrocytes
An important effect of thyroid hormones on brain development has been well documented (1) and T4 nuclear receptors have been described in whole brain of several animal species (2–5). In developing chick brain, T3 nuclear receptors are distributed in both neurons and glial cells (6). We have shown that astrocytes from 2 and 12 day old mice in culture produce Nerve Growth Factor (NGF) (7) and that brain NGF concentrations in the developing mouse are thyroid hormone responsive (8). This data suggested that astrocytes may have T3 receptors. However, recent studies, in abstract form, report the absence of T3 receptors in 17 day fetal rat brain glial cells (9). No data are currently available regarding T3 receptors in astrocytes of developing rodent brain. Therefore, the present study was conducted to characterize the T3 receptor in mouse neonatal astrocytes.
KeywordsThyroid Hormone Nerve Growth Factor Mouse Astrocyte Brain Astrocyte Maximal Binding Capacity
Unable to display preview. Download preview PDF.
- 1.Grave GD. Thyroid Hormones and Brain Development, Raven Press, New York, 1977.Google Scholar
- 7.Tarris R, Weichsel Jr ME, et al. Submitted.Google Scholar
- 9.Kolodny JM, Leonard JL, and Larsen PR. Program of LX Meeting American Thyroid Association, T2, Sept. 1984.Google Scholar
- 12.Hill BT and Whatley S. FEES Lett 56: 1975.Google Scholar
- 13.Lowry OH, Rosebrough NJ, Farr AL, et al. J Biol Chem 252: 6799, 1951.Google Scholar
- 14.Sokoloff L and Kennedy C. In GE Gaull (ed), Biology of Brain Dysfunc-tion, Vol. 2, Plenum Press, New York, 1973, p 295.Google Scholar