Thyroid Hormone Stimulates Alkaline Phosphatase Activity in Cultured Osteoblastic Cells with T3 Nuclear Receptors

  • Kanji Sato
  • Doo Chol Han
  • Yuko Fujii
  • Kazuo Shizume


It is well known that serum alkaline phosphatase (Al-P) activity is frequently increased in patients with Graves’ disease and that the increased Al-P is of bone origin (1). However, the mechanism of hyperphosphatasia had not been elucidated.


Thyroid Hormone Alkaline Phosphatase Activity Hyperthyroid Patient Thyroid Hormone Concentration Bone Origin 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Kanji Sato
    • 1
  • Doo Chol Han
    • 1
  • Yuko Fujii
    • 2
  • Kazuo Shizume
    • 1
  1. 1.Department of MedicineInstitute of Clinical Endocrinology Tokyo Women’s Medical CollegeShinjuku, TokyoJapan
  2. 2.Foundation of Growth ScienceShinjuku, TokyoJapan

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