Hypothyroidism Inhibits the Rapid Response of mRNA-S14 to Carbohydrate Feeding

  • Cary N. Mariash
  • Steve Seelig
  • Harold L. Schwartz
  • Donald B. Jump
  • Jack H. Oppenheimer


The hormonal and metabolic regulation of hepatic lipogenic enzymes has been under intense investigation for a number of years. These enzymes, and their respective mRNAs, are influenced both by thyroid hormone, as well as those hormones and compounds involved in the metabolism of carbohydrates (1–4). We have recently demonstrated a synergistic relationship between T3 and carbohydrates in the regulation of several of these enzymes (5), and have used translational assays to demonstrate that this interaction is reflected by the activity of the specific mRNA coding for the enzyme (6–8).


Thyroid Hormone Hepatocyte Culture Orotic Acid Guanidine Thiocyanate Hypothyroid Animal 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Cary N. Mariash
    • 1
  • Steve Seelig
    • 1
  • Harold L. Schwartz
    • 1
  • Donald B. Jump
    • 1
  • Jack H. Oppenheimer
    • 1
  1. 1.Division of Endocrinology and MetabolismDepartment of Medicine, University of MinnesotaMinneapolisUSA

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