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Prostacyclin (PGI2) Production in Hyperthyroid Rats and Patients with Graves’ Disease

  • T. Noguchi
  • Y. Kazama
  • Y. Kanemaru
  • T. Onaya

Abstract

Prostaglandins can stimulate thyroid hormone secretion from the thyroid gland (1). Conversely, T3 can stimulate prostacyclin synthesis by cultured vascular smooth muscle cells (2). These findings seem very interesting for understanding the mechanism of the anti-atherosclerotic action of thyroid hormone. Therefore, we have examined the effect of thyroid hormone administration in vivo on prostacyclin synthesis in rats, and the mechanisms of thyroid hormone action were also investigated.

Keywords

Thyroid Hormone Aortic Ring Phospholipid Content Antithyroid Drug Hyperthyroid Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Onaya T and Solomon DH. Endocrinology 86: 423, 1970.PubMedCrossRefGoogle Scholar
  2. 2.
    Nakao J, Chang WC, Murota S, et al. Atherosclerosis 39: 439, 1981.PubMedCrossRefGoogle Scholar
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    Noguchi T, Kazama Y, Kanemaru Y, et al. Prostaglandins (in press).Google Scholar
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    Folch J, Lees M, and Sloane-Stanley GH. J Biol Chem 226: 497, 1957.PubMedGoogle Scholar
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    Eisenberg S, Stein Y, and Stein 0. Biochim Biophys Acta 164: 205, 1968.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • T. Noguchi
    • 1
  • Y. Kazama
    • 1
  • Y. Kanemaru
    • 1
  • T. Onaya
    • 1
  1. 1.The Third Department of Internal MedicineUniversity of Yamanashi Medical SchoolTamaho, Yamanashi-kenJapan

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