Prostacyclin (PGI2) Production in Hyperthyroid Rats and Patients with Graves’ Disease
Prostaglandins can stimulate thyroid hormone secretion from the thyroid gland (1). Conversely, T3 can stimulate prostacyclin synthesis by cultured vascular smooth muscle cells (2). These findings seem very interesting for understanding the mechanism of the anti-atherosclerotic action of thyroid hormone. Therefore, we have examined the effect of thyroid hormone administration in vivo on prostacyclin synthesis in rats, and the mechanisms of thyroid hormone action were also investigated.
KeywordsThyroid Hormone Aortic Ring Phospholipid Content Antithyroid Drug Hyperthyroid Patient
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