Thyroid Hormone Stimulates Red Blood Cell Ca++-Dependent ATPase Activity Through a “Non-Hormonal” Effect

  • Giuseppe Costante
  • Georges Sand
  • Denis Connart
  • Daniel Glinoer


Thyroid hormones (TH) elicit a wide variety of metabolic and physiological responses in several tissues of higher organisms. The majority of these effects require the interaction of TH with protein receptors located at the cell nucleus. However, exranuclear actions of TH have elicited growing interest during the last decade. Red blood cells have been shown to possess plasma membrane-binding sites for both T3 and T4. Using this as a cellular model, a direct stimulation of erythrocyte membrane Ca++-dependent ATPase (Ca++-ATPase) by physiological concentrations of TH has recently been demonstrated (1,2). Among TH analogues, T4 exerts the highest stimulatory effect on basal enzyme activity which is not dependent upon prior conversion to T3 (3). This effect of T4 requires the mediation of calmodulin (CaM), an ubiquitous cytosolic protein which plays a major role in the regulation of Ca++-ATPase (4).


Thyroid Hormone Erythrocyte Membrane Human Erythrocyte Membrane Dependent ATPase Dependent ATPase Activity 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Giuseppe Costante
    • 1
  • Georges Sand
    • 1
  • Denis Connart
    • 1
  • Daniel Glinoer
    • 1
  1. 1.Laboratory of Radioisotopes and Department of Internal Medicine, Hospital Saint-PierreUniversite Libre de BruxellesBrusselsBelgium

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