Hereditable Defects in Thyroid Peroxidase Function

  • L. J. DeGroot
  • L. Portman


The biochemical pathway leading to secretion of thyroid hormones depends on iodide transport, iodide oxidation, and binding of tyrosyl residues present in thyroglobulin (Tg). This requires a normal thyroid peroxidase (TPO), T2O2 generating system, and supply of iodide and Tg. Abnormalities of this process will be reviewed. Patients with defects of hormone synthesis typically display a compensatory growth of the thyroid and hypothyroidism or cretinism depending on the severity and time of onset of the thyroid hormone deficiency. These disorders are probably all congenital, however, the underlying genetics is not fully understood.


Multinodular Goiter Apical Cell Membrane Nontoxic Goiter NADPH Cytochrome Thyroid Hormone Deficiency 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • L. J. DeGroot
    • 1
  • L. Portman
    • 1
  1. 1.Thyroid Study UnitUniversity of ChicagoChicagoUSA

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