Regulation of 19,000 Mr Soluble Protein and High Mobility Group Protein (HMG 14) Phosphorylation by Triiodothyronine (T3) in Primary Astrocytic Cultures

  • Jean-Michel Gavaret
  • Min Luo
  • Robert Faure


While most of the information available concerns the numerous effects of thyroid hormones on the maturation of neurons, it has been noted that glial cells also are affected by thyroid status (1). In order to further investigate the mechanism of action of thyroid hormones on the brain, we developed a system of cultured cells from cerebral hemispheres of postnatal rat, which are predominantly composed of astrocytes (2). It is now well established that protein phosphorylation-dephosphorylation is a major general mechanism by which external stimuli controls the intracellular activity. Therefore, in this study, we have examined the effects of triiodothyronine (T3) on protein phosphorylation in different subcellular fractions of cultured astrocytes.


Thyroid Hormone Protein Phosphorylation High Mobility Group Thyroid Status American Thyroid Association 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jean-Michel Gavaret
    • 1
  • Min Luo
    • 1
  • Robert Faure
    • 1
  1. 1.Unite de Recherche en ThyroideLe Centre Hospitalier de l’Universite LavalQuebecCanada

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