Selective Inhibition by Monoamine Oxidase (MAO) Inhibitors of the Iodotyrosine Formation Induced by MAO Substrates in Bovine Thyroid Tissue
Monoamine oxidase (EC 220.127.116.11) (MAO) may probably be involved in the hydrogen peroxide generation required for the iodination process in the thyroid tissue (1,2). Biogenic amines have been demonstrated to be able to generate hydrogen peroxide and to increase iodine organification in thyroid tissue, and these effects were decreased by MAO inhibitors (3,4). On the other hand, it was observed that rat thyroid MAO activity was increased by TSH administration and reduced after hypophysectomy (2).
KeywordsMonoamine Oxidase Biogenic Amine Thyroid Tissue Generate Hydrogen Peroxide Common Substrate
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