Emerging Concepts in Inherited Disorders of Thyroid Metabolism
Congenital disorders of thyroid metabolism may result from complete or partial blockage at any biochemical step in hormone synthesis, storage, secretion, delivery, or utilization. Our understanding of inborn errors of thyroid awaited the development of sophisticated biochemical investigative tests pioneered by Stanbury just over 35 years ago (1). Since then, there has been an enormous growth of our knowledge of these disorders. The detailed molecular mechanism in each defect has been only partially elucidated but progress in this field has greatly assisted our knowledge of normal thyroid physiology.
KeywordsThyroid Hormone Multinodular Goiter Thyroxine Binding Globulin Goiter Prevalence Thyroid Metabolism
Unable to display preview. Download preview PDF.