T3 and rT3 Generation from Exogenous and Endogenous T4 in Perfused Dog Thyroids

  • Peter Laurberg
  • Hans Orskov


In previous studies, we found evidence for intrathyroidal deiodination of T4 released from thyroglobulin (endogenous T4) to T3 and rT3 by iodothyronine deiodinases similar to those found in the liver (1). This is the major mechanism behind the relative hypersecretion of T3 and rT3 compared to T4 observed in thyroid perfusion studies (1).


Buffer Medium Iodothyronine Deiodinases Hormone Binding Protein Thyroid Hormone Binding Thyroid Hormone Binding Protein 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Peter Laurberg
    • 1
  • Hans Orskov
    • 1
  1. 1.Second University Clinic of Internal Medicine KommunehospitaletAarhus CDenmark

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