Residual Capacity for Iodide Organification in Human Thyroid Slices Provoked by Hydrogen Peroxide
Iodination of tyrosyl residues in thyroglobulin is one of the essential steps of biosynthesis of thyroid hormones. In 1944, Dempsy demonstrated a peroxidase in the thyroid histochemically (1). Since then, the study concerned with thyroid hormone production has progressed greatly. So far, evidence has been provided, indicating that thyroid peroxidase is the key enzyme for iodide organification in the thyroid. Subsequently, it was also demonstrated that the process of thyroid hormone synthesis involves hydrogen peroxide.
KeywordsThyroid Hormone Thyroid Tissue H202 Generation Adenoma Tissue Thyroid Hormone Synthesis
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