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Residual Capacity for Iodide Organification in Human Thyroid Slices Provoked by Hydrogen Peroxide

  • Toshiro Nakashima
  • Shiro Noguchi
  • Ken Okamura
  • Akiyo Shiroozu
  • Kaoru Sato
  • Hiroshi Ikenoue
  • Masatoshi Fujishima

Abstract

Iodination of tyrosyl residues in thyroglobulin is one of the essential steps of biosynthesis of thyroid hormones. In 1944, Dempsy demonstrated a peroxidase in the thyroid histochemically (1). Since then, the study concerned with thyroid hormone production has progressed greatly. So far, evidence has been provided, indicating that thyroid peroxidase is the key enzyme for iodide organification in the thyroid. Subsequently, it was also demonstrated that the process of thyroid hormone synthesis involves hydrogen peroxide.

Keywords

Thyroid Hormone Thyroid Tissue H202 Generation Adenoma Tissue Thyroid Hormone Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Dempsy EW. Endocrinology 34: 27, 1944.CrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Toshiro Nakashima
    • 1
  • Shiro Noguchi
    • 2
  • Ken Okamura
    • 3
  • Akiyo Shiroozu
    • 3
  • Kaoru Sato
    • 3
  • Hiroshi Ikenoue
    • 3
  • Masatoshi Fujishima
    • 3
  1. 1.The Kaita HospitalFukuokaJapan
  2. 2.Noguchi HospitalBeppuJapan
  3. 3.Kyushu University Medical SchoolFukuokaJapan

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