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Enhanced Rate of Cellular Uptake of Thyroxine (T4) from Sera of Subjects with Familial Dysalbuminemic Hyperthyroxinemia (FDH)

  • B. N. Premachandra
  • I. K. Williams
  • B. C. Nisula
  • J. Wortsman

Abstract

Recent investigations in our laboratory have shown that in several individuals with familial dysalbuminemic hyperthyroxinemia (FDH) and with normal serum free thyroxine (FT4) concentration, sex hormone-binding glob­ulin (SHBG) levels were significantly elevated in relation to normal sub­jects (1). The elevation in serum SHBG was not an estrogen-mediated effect, as these subjects were either in post-menopausal state or other­wise had normal levels of serum cortisol-binding globulin (CBG). Since SHBG is sensitive to thyroid hormone (TH) action and has been observed to increase in hyperthyroidism (2), the SHBG increase in FDH subjects sug­gested the possibility that an enhanced rate of T4 uptake might occur in this syndrome, particularly in those tissues which have direct access to protein-bound T4 (e.g., liver). To further test the hypothesis of in­creased T4 tissue availability in FDH syndrome, T4 uptake from normal and FDH sera studied using red blood cells, lymphocytes, and an anionic resin sponge.

Keywords

Thyroid Hormone Cellular Uptake Serum Free Thyroxine Normal Human Seron Serum SHBG 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • B. N. Premachandra
    • 1
    • 2
  • I. K. Williams
    • 1
    • 2
  • B. C. Nisula
    • 1
    • 2
  • J. Wortsman
    • 1
    • 2
  1. 1.VA Medical CenterWashington University, St. Louis, MO NIHBethesdaUSA
  2. 2.SIU Medical SchoolSpringfieldUSA

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