Advertisement

Thyrotropin-Releasing Hormone Action in Thyrotropic Cells: Mechanism of Stimulation of Thyroid-Stimulating Hormone Secretion

  • Marvin C. Gershengorn

Abstract

Production of pituitary thyrotropin (thyroid-stimulating hormone; TSH), the major modulator of secretion of L-triiodothyronine (L-T3) and L-thyroxine (L-T4) from the thyroid gland, is, in turn, regulated by the circulating thyroid hormone level. Superimposed on the pituitary-thyroid feedback system is a modulation by the central nervous system that appears to be mediated, in large part, by hypothalamic thyrotropin-releasing hormone (TRH). The studies described herein were undertaken to define the intracellular events that mediate TRH stimulation of the thyrotroph, in particular, TRH stimulation of TSH secretion.

Keywords

Arachidonic Acid Exocytotic Process Thyrotropic Cell Circulate Thyroid Hormone Level Pituitary Thyrotropin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gershengorn MC: Endocrinology 102: 1122, 1978.PubMedCrossRefGoogle Scholar
  2. 2.
    Gershengorn MC, Cohen M, and Hoffstein ST: Endocrinology 103: 648, 1978.PubMedCrossRefGoogle Scholar
  3. 3.
    Gershengorn MC: In JH Oppenheimer and HH Samuels (eds), Molecular Basis of Thyroid Hormone Action, Academic Press, New York and London, 1983, p 387.CrossRefGoogle Scholar
  4. 4.
    Furth J, Moy P, Hershman JM, et al. Arch Pathol 96: 217, 1973.PubMedGoogle Scholar
  5. 5.
    Rasmussen H, and Barrett PQ: Physiol Rev 64: 938, 1984.PubMedGoogle Scholar
  6. 6.
    Douglas WW: Ciba Found Symp 54: 61, 1978.PubMedGoogle Scholar
  7. 7.
    Berridge MJ: Biochem J 220: 345, 1984.PubMedGoogle Scholar
  8. 8.
    Nishizuka Y: Nature (Lond) 308: 693, 1984.CrossRefGoogle Scholar
  9. 9.
    Brenner-Gati L, and Gershengorn MC: Endocrinology, in press.Google Scholar
  10. 10.
    Geras EJ, and Gershengorn MC: Am J Physiol 242 (Endocrinol Metab 5): E109, 1982.PubMedGoogle Scholar
  11. 11.
    Geras E, Rebecchi MJ, and Gershengorn MC. Endocrinology 110: 901, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Gershengorn MC, and Thaw C: Am J Physiol 243 (Endocrinol Metab 6): E298, 1982.PubMedGoogle Scholar
  13. 13.
    Gershengorn MC, Geras E, Rebecchi MJ, et al. J Biol Chem 256: 1 2445, 1981.Google Scholar
  14. 14.
    Kolesnick RN, Musacchio I, Thaw C, et al. Endocrinology 114: 671, 1984.PubMedCrossRefGoogle Scholar
  15. 15.
    Gershengorn MC, Geras E, Purello VS, et al. J Biol Chem 259: 10675, 1984.PubMedGoogle Scholar
  16. 16.
    Gershengorn MC: Mol Cell Biochem 45: 163, 1982.PubMedCrossRefGoogle Scholar
  17. 17.
    Koenig RJ, Senator D, and Larsen PR: Biochem Biophys Res Commun 125: 353, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Marvin C. Gershengorn
    • 1
  1. 1.Division of Endocrinology and Metabolism, Department of MedicineCornell University Medical College and the New York HospitalNew YorkUSA

Personalised recommendations