Thyrotropin-Releasing Hormone Action in Thyrotropic Cells: Mechanism of Stimulation of Thyroid-Stimulating Hormone Secretion

  • Marvin C. Gershengorn


Production of pituitary thyrotropin (thyroid-stimulating hormone; TSH), the major modulator of secretion of L-triiodothyronine (L-T3) and L-thyroxine (L-T4) from the thyroid gland, is, in turn, regulated by the circulating thyroid hormone level. Superimposed on the pituitary-thyroid feedback system is a modulation by the central nervous system that appears to be mediated, in large part, by hypothalamic thyrotropin-releasing hormone (TRH). The studies described herein were undertaken to define the intracellular events that mediate TRH stimulation of the thyrotroph, in particular, TRH stimulation of TSH secretion.


Arachidonic Acid Exocytotic Process Thyrotropic Cell Circulate Thyroid Hormone Level Pituitary Thyrotropin 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Marvin C. Gershengorn
    • 1
  1. 1.Division of Endocrinology and Metabolism, Department of MedicineCornell University Medical College and the New York HospitalNew YorkUSA

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