The Mitochondrial DNA of Neurospora Crassa: Deletion by Intramolecular Recombination and the Expression of Mitochondrial Genes

  • Hans de Vries
  • Cobi Schrage
  • Jenny C. De Jonge
Part of the Basic Life Sciences book series (BLSC, volume 40)


Stopper (stp) mutants of Neurospora crassa are characterized by an irregular stop-start growth pattern on agar plates or in tubes (3). All stoppers isolated so far have grossly abnormal mitochondrial DNA (mtDNA) (3,9,13) and are deficient in respiratory chain components. The mutant stp[E35], isolated in our laboratory, is an example of this category (9, 10). Cytochromes aa 3 and b are virtually absent in this mutant, and cytochrome c oxidase activity is only marginal (about 3% of wild-type activity). We have shown (10) that the absence of cytochrome c oxidase is not due to a blocked synthesis of its subunits, but rather to a defect in their assembly.


Mitochondrial Genome tRNA Gene Neurospora Crassa Electron Paramagnetic Reso Stopper Mutant 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Hans de Vries
    • 1
  • Cobi Schrage
    • 1
  • Jenny C. De Jonge
    • 1
  1. 1.Laboratory of Physiological ChemistryState University at GroningenGroningenThe Netherlands

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