Abstract
Evidence is increasingly accumulating to indicate that eukaryotic RNA polymerases do not recognize promoter sequences encoded in DNA as does their prokaryotic counterpart. Rather, eukaryotic promoter/regulatory regions encompass sites that bind multiple transcription factors. Some of these factors are “mechanical” in nature, such as the TATA box factor required for genes transcribed by RNA polymerase II. Other factors are gene-specific and bind to sequences found upstream of the TATA box. The interplay of the latter class of factors with regulatory sequences is responsible for regulation of transcription.
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References
Arcangioli, B., and B. Lescure (1985) Identification of proteins involved in the regulation of yeast iso-1-cytochrome c expression oxygen. EMBO J. 4:2627–2633.
Bram, R.J., and R.D. Romberg (1985) Specific protein binding to far upstream activating sequences in polymerase II promoters. Proc. Natl. Acad. Sci., USA 82:43–47.
Faye, G., D. Leung, K. Tatchell, B. Hall, and B. Smith (1981) Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene. Proc. Natl. Acad. Sci., USA 78:2258–2262.
Ginegar, E., S.M. Varnum, and M. Ptashne (1985) Specific DNA binding of GAL4, a positive regulatory protein of yeast. Cell 48:676–774.
Guarente, L. (1984) Yeast promoters: Positive and negative elements. Cell 36:799–800.
Guarente, L., and E. Hoar (1984) Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the TATA box. Proc. Natl. Acad. Sci., USA 81: 7860–7864.
Guarente, L., and T. Mason (1983) Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell 32:1279–1286.
Guarente, L., B. Lalonde, P. Gifford, and E. Alani (1984) Distinctively regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S . cerevisiae. Cell 36:504–511.
Hahn, S., E. Hoar, and L. Guarente (1985) Each of three “TATA elements” specifies a subset of the transcription initiation sites at the CYC1 promoter of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci., USA 82:8562–8566.
Hope, I., and K. Struhl (1985) GCN4 protein synthesized in vitro binds HIS3 regulatory sequences’ implications for general control of amino acid biosynthetic genes in yeast. Cell 43:177–188.
Lalonde, B., B. Arcangioli, and L. Guarente (1986) A single yeast upstream activation site UAS1 has two distinct regions essential for its activity. Mol. Cell. Biol, (submitted for publication).
Pinkham, J.L., and L. Guarente (1985) Cloning and molecular analysis of the HAP2 locus: A global regulator of respiratory genes in S. cerevisiae. Mol. Cell. Biol. 5:3410–3416.
Sherman, F., and J. Stewart (1971) Genetics and biosynthesis of cytochromec. Ann. Rev. Genet. 5:257–296.
Struhl, K. (1982) The yeast HIS3 promoter contains at least two distinct elements. Proc. Natl. Acad. Sci., USA 79:7385–7389.
Struhl, K. (1984) Genetic properties and chromatin structure of the yeast gal regulatory element: An enhancer-like sequence. Proc. Natl. Acad. Sci., USA 81:7865–7869.
Verdiere, J., F. Creusot, L. Guarente, and P.P. Slonimski (1986) The overproducing CYP1 and the underproducing hap1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromesc. Curr. Genet. 10:339–342.
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© 1986 Plenum Press, New York
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Guarente, L.P. (1986). Regulation of the Yeast CYC1 Gene. In: Wickner, R.B., et al. Extrachromosomal Elements in Lower Eukaryotes. Basic Life Sciences, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5251-8_39
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DOI: https://doi.org/10.1007/978-1-4684-5251-8_39
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