Regulation of the Yeast CYC1 Gene
Evidence is increasingly accumulating to indicate that eukaryotic RNA polymerases do not recognize promoter sequences encoded in DNA as does their prokaryotic counterpart. Rather, eukaryotic promoter/regulatory regions encompass sites that bind multiple transcription factors. Some of these factors are “mechanical” in nature, such as the TATA box factor required for genes transcribed by RNA polymerase II. Other factors are gene-specific and bind to sequences found upstream of the TATA box. The interplay of the latter class of factors with regulatory sequences is responsible for regulation of transcription.
KeywordsInitiation Site CYCI Gene TATA Element Yeast Promoter Nonfermentable Carbon Source
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