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The Replication of Double-Stranded RNA

  • Anita M. Newman
  • Calvin S. McLaughlin
Part of the Basic Life Sciences book series (BLSC, volume 40)

Abstract

A wide variety of fungi harbor virus-like particles (VLPs), approximately 40 nm in diameter, that contain double-stranded RNA (dsRNA) genomes (10). In some ways, these dsRNA genomes are more similar to plasmids than to true viruses. They are noninfectious and are transferred between cells only under conditions of cytoplasmic mixing, such as occurs in mating or other natural or artificial means of cell fusion (10,42). The particles are stably maintained by vertical transmission at levels that are characteristic of the growth conditions of the culture (10,30) or the particular strain in question (30). Although the virus-like nature of the particles derives from their possession of a protein coat, this coat does possess a transcriptase activity (8,19,47,48), presumably a necessary function for the replication of a dsRNA genome in a previously uninfected cell.

Keywords

Hybrid Material Single Strand Yeast Killer dsRNA Molecule dsRNA Genome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Anita M. Newman
    • 1
  • Calvin S. McLaughlin
    • 1
  1. 1.Department of Biological Chemistry, California College of MedicineUniversity of CaliforniaIrvineUSA

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