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Measurement of Subcellular Ions by X-ray Microanalysis for Evidence of Hepatotoxicity

  • J. R. Millette
  • A. L. Allenspach
  • P. J. Clark
  • J. A. Stober
  • T. Mills
  • C. Weiler
  • D. Black

Abstract

This chapter is largely an elaboration of a paper which was presented at the Forensic, Occupational and Environmental Health Symposium at the 1985 joint national meetings of the Electron Microscopy Society of America and the Microbeam Analysis Society in Louisville, Kentucky. An extended abstract of that presentation has been published by San Francisco Press.

Keywords

Carbon Tetrachloride Bile Canaliculus Fourth Degree Mouse Liver Tissue Phase Contrast Photomicrograph 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    F. A. X. Schanne, A.B. Kane, E.E. Young and J.L. Farber. Calcium dependence of toxic cell death: A final common pathway. Science 206: 700–703 (1979)CrossRefGoogle Scholar
  2. 2.
    E. S. Reynolds. Liver parenchymal cell injury. J. Cell Biol. 19: 139–57 (1963)CrossRefGoogle Scholar
  3. 3.
    F. A. Smuckler. Studies on carbon tetrachloride intoxication. Lab. Invest. 15: 57–166 (1966)Google Scholar
  4. 4.
    L. Moore, G. R. Davenport and E. J. Landan. Calcium uptake of a rat liver microsanal subcellular fraction in response to in vivo administration of carbon tetrachloride. J. Biol. Chem. 251: 1197–1210 (1976)Google Scholar
  5. 5.
    D. Parsons, D. J. Bellotto, W. W. Schultz, M. Buja and H. K. Hagler. Toward routine cryoultramicrotamy. EMSA Bulletin 14: 4960 (1985)Google Scholar
  6. 6.
    C. E. Fiori, R. L. Mykelbust and K. Gorlen. Sequential Simplex: a procedure for resolving spectral interference in energy dispersive x-ray spectroscopy. NBS Spec. Pub. 604. Proc. Workshop on Energy Dispersive X-ray Spectroscopy, Gaithersburg, MD. Apr. 23–25, 1979. 233–72 (1981)Google Scholar
  7. 7.
    C. E. Fiori, C. R. Swyt and K. Gorlen. Application of the top-hat digital filter to a non-linear spectral unraveling procedure in energy dispersive x-ray microanalysis. In: Microbe= Analysis (R. Geiss, ed.) San Francisco Press, 320–324 (1981)Google Scholar
  8. 8.
    H. Shuman, A. V. Sanlyo and A. P. Sanlyo. Quantitative electron probe microanalysis of biological thin sections: methods and validity. Ultranicroscopy 1: 317–39 (1976)CrossRefGoogle Scholar
  9. 9.
    T. F. Phillips and A. F. Boyne. Liquid nitrogen-based quick freezing: experiences with bounce-free delivery of cholinergic nerve terminals to a metal surface. J. Electron Microsc. Tech. 1: 9–15 (1984)CrossRefGoogle Scholar
  10. 10.
    T. A. Hall. Biological x-ray microanalysis. J. Microsc. 117: 145 (1979)CrossRefGoogle Scholar
  11. 11.
    J. M. Tormey. Improved methods for x-ray microanalysis of cardiac muscle. In: Microbe= Analysis (R. Gooley, ed.) San Francisco Press 221–228 (1983)Google Scholar
  12. 12.
    G. M. Roamans. Quantitative x-ray microanalysis of thin sections in M.A. Hayat (ed). X-ray Microanalysis in Biology. Univ. Park Press, Baltimore 401–453 (1980)Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. R. Millette
    • 1
  • A. L. Allenspach
    • 2
  • P. J. Clark
    • 1
  • J. A. Stober
    • 1
  • T. Mills
    • 3
  • C. Weiler
    • 3
  • D. Black
    • 3
  1. 1.Toxicology and Microbiology DivisionHealth Effects Laboratory USEPACincinnatiUSA
  2. 2.Department of ZoologyMiami UniversityOxfordUSA
  3. 3.Computer Sciences CorporationFalls ChurchUSA

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