Immune Reactivities During the Precancer and Early Cancer Periods: Novel Approaches for Immunomodulation
It is widely accepted that transformation of normal cells is associated with the activation or alteration of cellular oncogenes (1). Transformed cells have also, in many cases, the ability to propagate via an autocrine growth pathway, i.e. to synthesize and utilize their own growth factors (2). Activated one genes and autocrine growth, being intrinsic characteristics of the transformed clone, may not suffice tor such a clone to progress into a fully fledged cancer. The in-vivo progression of the transformed clone would depend, at least so some extent, also on its ability to survive in the milieu provided by the host. Such environmental factors may include angiogenesis (3); interaction with neighbouring tissues and cells (4); supply of growth promoting factors such as hormones (5) and immunological pressure (6). Conceivably, only those transformed cells which are endowed with the capacity to adapt themselves to host-derived environmental factors would be able to progress towards malignancy.
KeywordsEndometrial Carcinoma T2D4 Cell Precancer Period Mitogenic Response Cellular Oncogene
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