An Overview of the Current Understanding and Management of the Non-Hodgkin’s Lymphomas

  • Ellen R. Gaynor
  • John E. Ultmann
Part of the NATO ASI Series book series (NSSA, volume 120)


The hematologic malignancies have always provided the model tumor system tor the oncologist. These tumors traditionally have been among the most responsive to chemotherapy and hence chemotherapeutic developments stemmed largely from knowledge gained from the management of these diseases. What has been lacking is an understanding of the malignant process itself and so while we have been able to control and often cure these diseases, a void has existed in our understanding of basic pathophysiology. The past several years have brought tremendous developments in the fields of cytogenetics, immunology, molecular biology, and virology. Whereas previously we have been able to speak of these diseases in merely descriptive terms, we are now quickly gaining an understanding of the events leading to the phenomenon of malignant transformation. It is apparent that once the process is understood, it will be merely a matter of time before we are better able to control the process. While the gap between basic pathophysiology information and therapeutic application is a reality, it probably will not be an insurmountable hurdle.


Chronic Lymphocytic Leukemia Complete Remission Rate Hairy Cell Leukemia Adoptive Immunotherapy Immunoglobulin Gene 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Ellen R. Gaynor
    • 1
  • John E. Ultmann
    • 1
  1. 1.Department of MedicineUniversity of Chicago and the University of Chicago Cancer Research CenterChicagoUSA

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