Acquisition of Metastatic Properties via Somatic Cell Fusion: Implications for Tumor Progression in Vivo
Somatic hybridization of normal somatic cells with neoplastic cells has been widely adopted as a tool to identify chromosomes or genes involved in the suppression or expression of malignancy. Originally, the neoplastic trait appeared to be dominant (1,2) but now experimental results seem to indicate that fusion of transformed cells with normal cells results in hybrids that are, initially at least, non tumorigenic (3,4). Tumorigenic lines, when they arise, are thought to do so by chromosomal segregation and the loss of specific chromosomes (5,6). This suppression of in vivo growth capacity of tumorigenic lines has often been referred to as “suppression of malignancy” and recently it has been proposed that a group of recessive genes, the socalled “tumor suppressors” or “anti-oncogenes” are implicated in this process (7).
KeywordsSomatic Hybridization Cell Fusion Mixed Lymphocyte Culture Metastatic Property Premature Chromosome Condensation
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