Proteins Encoded by the Human T-Lymphotropic Virus Type III/ Lymphadenopathy Associated Virus (HTLV-III/LAV) Genes

  • M. G. Sarngadharan
  • Fulvia diMarzo Veronese
  • Robert C. Gallo
Part of the NATO ASI Series book series (NSSA, volume 120)


Human T-lymphotropic virus-type III/lymphadenopathy associated virus (HTLV-III/LAV) has been identified as the primary etiologic agent of human acquired immune deficiency syndrome (AIDS) (1–4). Among members of epidemiologically identified risk groups of AIDS, there has been a high prevalence of HTLV-III/LAV infection irrespective of whether they have clinical AIDS or have only some signs and symptoms associated with AIDS [AIDS-related complex (ARC)], or are completely free of any disease symptoms (4–6). Thus a significant proportion (up to 50 or 60 %), depending on where they live) of homosexual males at risk for AIDS have serum antibodies to HTLV-III/LAV proteins (6,7). Infectious virus has been isolated from lymphocyte cultures derived from many of these asymptomatic antibody-positive individuals (2,8). HTLV-III/LAV-infection through contaminated blood has been identified as the cause of AIDS in transfusion recipients with no other risk factor for AIDS (9,10).


Acquire Immune Deficiency Syndrome Bovine Leukemia Virus Equine Infectious Anemia Virus Acquire Immune Deficiency Syndrome Patient Acquire Immune Deficiency Syndrome Virus 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. G. Sarngadharan
    • 1
  • Fulvia diMarzo Veronese
    • 1
  • Robert C. Gallo
    • 2
  1. 1.Department of Cell BiologyBionetics Research, Inc.RockvilleUSA
  2. 2.Laboratory of Tumor Cell BiologyNational Cancer InstituteBethesdaUSA

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