Molecular Biology of the Human T-Lymphotropic Retroviruses

  • Flossie Wong-Staal
Part of the NATO ASI Series book series (NSSA, volume 120)


There are only three human retroviruses identified to date. Remark­ably, they share a number of common properties, most notably the tropism for the OKT4+ helper T lymphocyte. For this reason, they have been named human T-lymphotropic viruses or HTLV (see Gallo and Wong-Staal, this volume). They are also associated with two naturally occurring diseases: HTLV type I with an aggressive form of leukemia called adult T-cell leukemia (ATL), and HTLV type III with the acquired immunodeficiency syndrome (AIDS). This chapter will summarize the molecular biology of this group of viruses, including both our current concept of the molecular mechanism of pathogenesis of these viruses as well as application of some of these studies tor development of diagnostic and preventive measures.


Bovine Leukemia Virus Hairy Cell Leukemia Equine Infectious Anemia Virus Chloramphenicol Acetyl Transferase Rous Sarcoma Virus 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Flossie Wong-Staal
    • 1
  1. 1.Laboratory of Tumor Cell BiologyNational Cancer Institute National Institutes of HealthBethesdaUSA

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