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Oncogenes in Development, Neoplasia, and Evolution

  • Fritz Anders
  • Annerose Anders
  • Manfred Schartl
  • Thomas Gronau
  • Wolfgang Lüke
  • Carl-Rudolf Schmidt
  • Angelika Barnekow
Part of the NATO ASI Series book series (NSSA, volume 120)

Abstract

The concept of genes that code for neoplastic transformation, called “oncogenes” today, originates from two sources: from virology and from animal genetics. The virological source can be traced back to the year 1911 when Peyton Rous discovered the virus that causes sarcoma in chickens. It took, however, about sixty years until evidence was brought about that the cancer determinants located in the genome of this virus and of related viruses (retroviruses) are genes (Huebner and Todaro, 1969; Bentvelzen, 1972). The source that originates from animal genetics can be traced back to the year 1928 when Myron Gordon, Georg Häussler, and Curt Kosswig indepently discovered that the F1 hybrids between certain domesticated ornamental breeds of the Central American fish species Xiphophorus maculatus (platyfish) and Xiphophorus helleri (swordtail) spontaneously develop melanoma that is inherited in the hybrid generations like the phenotype of any normal Mendelian gene located in the genome of the fish. Both, Rous’ sarcoma virus (RSV) and Xiphophorus fish represent up to date highly suitable models for research on oncogenes.

Keywords

Cellular Oncogene Regulatory Gene System Oncogene Amplification Murine Sarcoma Virus Melanoma Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Fritz Anders
    • 1
  • Annerose Anders
    • 1
  • Manfred Schartl
    • 1
    • 3
  • Thomas Gronau
    • 1
  • Wolfgang Lüke
    • 1
  • Carl-Rudolf Schmidt
    • 1
  • Angelika Barnekow
    • 2
  1. 1.Genetisches InstitutJustus-Liebig-Universität GiessenGiessenBundesrepublik Deutschland
  2. 2.Institut für Virologie (FB Humanmedizin)Justus-Liebig- Universität GiessenBundesrepublik Deutschland
  3. 3.Max-Planck-Institut für BiochemieMartinsriedBundesrepublik Deutschland

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