The Role of Cellular Glutathione in Protecting Mammalian Cells from X Radiation and Chemotherapy Agents in Vitro
Clonogenic cells in solid tumors are heterogeneous in their response to cancer therapeutic modalities, i.e., ionizing radiation and chemotherapy. The heterogeneity may be due to cellular factors, arising in clonally-derived tumors from genetic or epigenetic drift, or to microenvironmental factors arising from intratumor gradients in, for example, oxygen tension (pO2), glucose or other nutrients and pH. These factors may directly influence cellular response to treatment or may exert indirect influence by affecting, for example, cell proliferation.
KeywordsChemotherapy Agent Hypoxic Cell Cellular Glutathione Oxygen Effect Buthionine Sulfoximine
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