Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation
Cyclophosphamide and a few related compounds of the class of oxazaphosphorines are widely used in the chemotherapy of malignant diseases. Their antitumour efficacy is based on their cytotoxic activity against quickly proliferating cells. Beside this, these agents are strong immunosuppressants and a particularly high sensitivity of antibody-producing, proliferating B cells was postulated (1). In contrast, it could be shown that cyclophosphamide in non-toxic doses enhanced delayed-type hypersensitivity reactions, which indicated a selective effect of cyclophosphamide on T cells (2,3).
KeywordsHydrolysis Toxicity Leukemia Cyclophosphamide Prednisolone
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