Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation

  • R. Voegeli
  • J. Pohl
  • T. Reissmann
  • J. Stekar
  • P. Hilgard
Part of the NATO ASI Series book series (NSSA, volume 120)


Cyclophosphamide and a few related compounds of the class of oxazaphosphorines are widely used in the chemotherapy of malignant diseases. Their antitumour efficacy is based on their cytotoxic activity against quickly proliferating cells. Beside this, these agents are strong immunosuppressants and a particularly high sensitivity of antibody-producing, proliferating B cells was postulated (1). In contrast, it could be shown that cyclophosphamide in non-toxic doses enhanced delayed-type hypersensitivity reactions, which indicated a selective effect of cyclophosphamide on T cells (2,3).


Antitumour Efficacy Modify Cell Surface Human Peripheral Mononuclear Cell Adjuvant Combination Chemotherapy Host Antitumor Immunity 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. Voegeli
    • 1
  • J. Pohl
    • 1
  • T. Reissmann
    • 1
  • J. Stekar
    • 1
  • P. Hilgard
    • 1
  1. 1.Department of Experimental Cancer ResearchAsta-Werke AG Degussa Pharma GruppeBielefeld 14Germany

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