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Inhibitors of Terminal Transferase: A New Strategy for the Treatment of Human Leukemia

  • Ronald McCaffrey
  • Amy Ahrens
  • Richard Bell
  • Robert Duff
  • Henry Hoppe
  • Anne Lillquist
  • Zachary Spigelman
Part of the NATO ASI Series book series (NSSA, volume 120)

Abstract

Terminal deoxynucleotidyl transferase (TdT, EC 2.7.7.31) is a unique DNA polymerase which catalyzes the polymerization of deoxyribonucleotides on the 3’-hydroxyl ends of preformed oligo- or polydeoxynucleotide initiators, in a template-independent manner (1). Its expression is restricted, in normal animals, to subsets of primitive lymphocytes, and, in disease states, to the blast cells of certain forms of acute leukemia and diffuse lymphoma (2). For immunobiologists TdT has emerged as a useful marker for characterizing subsets of pre-B and pre-T lymphocytes (3–7). For physicians caring for patients with leukemia and lymphoma, neoplastic cell TdT status has turned out to be a useful criterion for patient assignment to therapeutically meaningful categories (8).

Keywords

Acute Leukemia Total Body Weight Thymus Weight Uncompetitive Inhibition Optimal Model System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Ronald McCaffrey
    • 1
  • Amy Ahrens
    • 1
  • Richard Bell
    • 1
  • Robert Duff
    • 1
  • Henry Hoppe
    • 1
  • Anne Lillquist
    • 1
  • Zachary Spigelman
    • 1
  1. 1.Section of Medical Oncology, Evans Memorial Department of Clinical ResearchBoston University Medical CenterBostonUSA

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