Inhibitors of Terminal Transferase: A New Strategy for the Treatment of Human Leukemia
Terminal deoxynucleotidyl transferase (TdT, EC 188.8.131.52) is a unique DNA polymerase which catalyzes the polymerization of deoxyribonucleotides on the 3’-hydroxyl ends of preformed oligo- or polydeoxynucleotide initiators, in a template-independent manner (1). Its expression is restricted, in normal animals, to subsets of primitive lymphocytes, and, in disease states, to the blast cells of certain forms of acute leukemia and diffuse lymphoma (2). For immunobiologists TdT has emerged as a useful marker for characterizing subsets of pre-B and pre-T lymphocytes (3–7). For physicians caring for patients with leukemia and lymphoma, neoplastic cell TdT status has turned out to be a useful criterion for patient assignment to therapeutically meaningful categories (8).
KeywordsAcute Leukemia Total Body Weight Thymus Weight Uncompetitive Inhibition Optimal Model System
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