Terminal Transferase and Adenosine Deaminase Activities in Human Neoplasia: Their Role in Modulating Cancer Treatment

  • P. S. Sarin
  • A. Thornton
  • D. Sun
Part of the NATO ASI Series book series (NSSA, volume 120)


Terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) are two enzyme markers that have been exstensively utilized to define the stage of the disease and the cell types involved in human leukemia B cell proliferation and severe combined immune deficiency syndrome (SCID). The use of these biological markers has been very useful in selecting treatment protocols for patients with leukemia/lymphoma and SCID.


Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia Adenosine Deaminase Blast Crisis 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • P. S. Sarin
    • 1
  • A. Thornton
    • 1
  • D. Sun
    • 1
  1. 1.Laboratory of Tumor Cell BiologyNational Cancer InstituteBethesdaUSA

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