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T-Cell Growth Factor (Interleukin-2)

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New Experimental Modalities in the Control of Neoplasia

Part of the book series: NATO ASI Series ((NSSA,volume 120))

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Abstract

Human peripheral blood lymphocytes (PBL) undergo a blast transformation when cultured with the plant lectin phytohemagglutinin (PHA) (1). These lymphocytes go through one or two cycles of cell division but could not be maintained in culture. The conditioned media from these lymphocyte cultures were found to have a variety of protein factors that affected growth and differentiation of human cells of many lineages (2). One of these factors was identified to specifically support the growth of activated human T-lymphocytes and was termed T-lymphocyte growth factor or T-cell growth factor (TCGF) (3,4). It is now more commonly referred to as interleukin-2 (IL-2). Detailed studies have been reported on the characteristics of the cells that produce IL-2, accessory cells and factors involved in its induction, and on the target cell that responds to IL-2 (5–9). IL-2 has been purified to homogeneity from normal peripheral blood lymphocytes and also from gibbon and human leukemic cell lines (10–13). cDNAs encoding this lymphokine have been isolated and sequenced (10,14,15) and the IL-2 gene characterized (16–17). The IL-2 gene has been localized to chromosome 4q (18).

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Authors and Affiliations

  1. Laboratory of Tumor Cell Biology, National Cancer Institute National Institutes of Health, Bethesda, MD, 20892, USA

    Suresh K. Arya & M. G. Sarngadharan

  2. Department of Cell Biology, Bionetics Research, Inc., Rockville, MD, 20850, USA

    Suresh K. Arya & M. G. Sarngadharan

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  1. Suresh K. Arya
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  2. M. G. Sarngadharan
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  1. University of Frankfurt, Frankfurt am Main, Federal Republic of Germany

    Prakash Chandra

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Arya, S.K., Sarngadharan, M.G. (1986). T-Cell Growth Factor (Interleukin-2). In: Chandra, P. (eds) New Experimental Modalities in the Control of Neoplasia. NATO ASI Series, vol 120. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5242-6_11

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  • DOI: https://doi.org/10.1007/978-1-4684-5242-6_11

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