Influenza pp 157-218 | Cite as

Influenza in Man

  • Edwin D. Kilbourne


The clinical expression of infection with influenza virus is variable and is partially influenced by the nature of the infecting virus but to a greater extent is modulated by the age, physiological state, and immunologic experience of the host. Depending on these factors, influenza infection may occur without symptoms, may kill, or, most frequently, may cause an acute, prostrating febrile illness attended by cough and myalgia (Fig. 7-1). Typically, the onset of the disease is rapid, and the degree of prostration and constitutional symptoms are out of proportion to the severity of the respiratory symptoms. Characteristically also, fever is short-lived (3-4 days), and recovery is rapid and uneventful. In its classical form influenza is “an unvarying disease caused by a varying virus” (Kil-bourne, 1980) and as such has been recognized through the centuries. However, even the typical case is diagnosed most easily in the context of an epidemic, and, indeed, epidemicity (simultaneous occurrence of other cases) is an important diagnostic clue.


Influenza Virus Hemagglutination Inhibit Influenza Infection Rheumatic Heart Disease Influenza Virus Infection 
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Copyright information

© Edwin D. Kilbourne, M.D. 1987

Authors and Affiliations

  • Edwin D. Kilbourne
    • 1
  1. 1.Mount Sinai School of MedicineCity University of New YorkNew YorkUSA

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