Influenza pp 33-56 | Cite as

Viral Structure and Composition

  • Edwin D. Kilbourne

Abstract

The influenza viruses comprise three types of viruses that are closely related in structure, chemical composition, and biological activity. These viruses, types A, B, and C, are pleomorphic enveloped viruses bearing surface projections (peplomers or spikes). Influenza A and B viruses contain four major structural proteins and three proteins with RNA replicase and transcriptase activity (Table 3–1). Eight segments of linear, single-stranded RNA are contained in separate nucleocapsids—rodlike structures of nucleoprotein (NP) (Heggeness et al., 1982)— with which the replicase and transcriptase proteins PB1, PB2, and PA are in close association in an RNP complex. The interior of the virus particle is delimited by repeating units of the matrix or membrane (M) protein in all three viral subtypes. The external spikes of influenza A and B viruses number 400 to 500 (Ruigrok et al., 1984) and comprise two different glycoproteins, the hemagglutinin (HA) and neuraminidase (NA). In the case of influenza C virus, only seven RNA segments and a single external glycoprotein have been demonstrated.

Keywords

Carbohydrate Influenza Polypeptide Trypsin Oligosaccharide 

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Copyright information

© Edwin D. Kilbourne, M.D. 1987

Authors and Affiliations

  • Edwin D. Kilbourne
    • 1
  1. 1.Mount Sinai School of MedicineCity University of New YorkNew YorkUSA

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