Influenza pp 291-345 | Cite as

The Control of Influenza

  • Edwin D. Kilbourne


Influenza is essentially an uncontrolled disease. The effect of current vaccination programs on morbidity is insignificant, and that on mortality marginal. Although effective artificial immunization against influenza was demonstrated soon after the first isolation of the virus from man (Chenoweth et al., 1936), the antigenic variability of the virus has hampered vaccine production and precluded effective control (Table 11–1). The transient protection afforded by presently available inactivated virus vaccines is related, in part, to a rapid decline in vaccine-induced homologous antibody but also to vaccine obsolescence as the result of continuous viral mutation to antigens unlike or less like those of viral predecessors contained in the vaccine (Kilbourne, 1978).


Influenza Virus Virus Vaccine Influenza Vaccine Influenza Vaccination Swine Influenza 
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Copyright information

© Edwin D. Kilbourne, M.D. 1987

Authors and Affiliations

  • Edwin D. Kilbourne
    • 1
  1. 1.Mount Sinai School of MedicineCity University of New YorkNew YorkUSA

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