Influenza pp 3-22 | Cite as

History of Influenza

  • Edwin D. Kilbourne


Because influenza is defined as much by its epidemiology as by its symptomatology, and because its causative virus rapidly and progressively changes, historical considerations are uniquely important in defining and evaluating this disease. The continual antigenic evolution of the virus is soon followed by specific and reciprocal changes in the immune status of infected human populations so that the pattern of influenza each year or decade reflects the experience of the community during the preceding one.


Influenza Virus Swine Influenza Swine Influenza Virus Causative Virus Hemagglutinin Antigen 
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  1. Anderson, S. G., and Burnet, F. M., 1947. Sporadic and minor epidemic incidence of influenza A in Victoria 1945–1946. I. Phase behaviour of influenza A strains in relation to epidemic characteristics, Aust. J. Exp. Biol. Med. 25:235–242.CrossRefGoogle Scholar
  2. Andrewes, C. H., 1951, Epidemiology of influenza in the light of the 1951 outbreak, Proc. R. Soc. Med. 44:803–804.PubMedGoogle Scholar
  3. Brill, S. J., and Gilfillan, R. F., 1977, Acute parotitis associated with influenza type A, N. Engl. J. Med. 296:1391–1392.PubMedCrossRefGoogle Scholar
  4. Burnet, F. M., and Clark, E., 1942, Influenza. A Survey of the Last 50 Years in the Light of Modern Work on the Virus of Epidemic Influenza. Monograph from the Walter and Eliza Hall Institute of Research in Pathology and Medicine. Macmillan, Melbourne, pp. 69–99.Google Scholar
  5. Chu, C. M., Andrewes, C. H., and Gledhill, A. W., 1950, Influenza in 1948–1949, Bull. WHO 3:187–214.PubMedGoogle Scholar
  6. Cockburn, W. C., Delon, P. J., and Ferreira, W., 1969, Origin and progress of the 1968–69 Hong Kong influenza epidemic, Bull. WHO 41:345–348.PubMedGoogle Scholar
  7. Collins, S. D., 1957, Influenza in the United States, 1887–1956. Public Health Monograph No. 48 ,U.S. Government Printing Office, Washington.Google Scholar
  8. Creighton, C., 1891, A History of Epidemics in Britain, AD 664–1666 ,Cambridge University Press, Cambridge.Google Scholar
  9. Crosby, A. W., 1976, Epidemic and Peace ,Greenwood Press, Westport, CT.Google Scholar
  10. Davenport, F. M., 1977, Reflections on the epidemiology of myxovirus infections, Med. Microbiol. Immunol. 164:69–76.PubMedCrossRefGoogle Scholar
  11. Francis, T., Jr., 1958, Influenza. Epidemiology. Influenza as a military problem, Preventive Medicine in World War II ,Vol. IV, Communicable Diseases (J. B. Coates, Jr., E. C. Hoff, and P. Hoff, eds.), The Surgeon General, Dept. of the Army, Washington, pp. 85–128.Google Scholar
  12. Francis, T., Jr., Salk, J. E., and Quilligan, J. J., 1947, Experience with vaccination against influenza in the Spring of 1947, Am. J. Public Health 37:1013–1016.CrossRefGoogle Scholar
  13. Grist, N. R., 1979, Pandemic influenza 1918, Br. Med. J. 2:1632–1633.PubMedCrossRefGoogle Scholar
  14. Harkness, J. W., Schild, G. C., Lamont, P. H., et al., 1972, Studies on relationships between human and porcine influenza. 1. Serological evidence of infection in swine in Great Britain with an influenza A virus antigenically like human Hong Kong/68 virus, Bull. WHO 46:709–719.PubMedGoogle Scholar
  15. Hewer, C. L., 1979, 1918 influenza epidemic, Br. Med. J. 1:199.PubMedCrossRefGoogle Scholar
  16. Hirsch, A, 1883, Acute Infective Diseases. Handbook of Geographical and Historical Pathology ,Vol. I (C. Creighton, trans.), New Sydenham Society, London.Google Scholar
  17. Kendal, A. P., Minuse, E., Maassab, H. F., et al., 1973, Influenza neuraminidase antibody patterns of man, Am. J. Epidemiol. 98:96–103.PubMedGoogle Scholar
  18. Kilbourne, E. D., 1959, Studies on influenza in the pandemic of 1957–58. III. Isolation of influenza A (Asian strain) viruses from influenza patients with pulmonary complications. Details of virus isolation and characterization of isolates, with quantitative comparison of isolation methods, J. Clin. Invest. 38:266–274.PubMedCrossRefGoogle Scholar
  19. Kilbourne, E. D.,, 1960, The severity of influenza as a reciprocal of host susceptibility, in: Ciba Foundation Study Group No. 4. Virus Virulence and Pathogenicity (G. E. W. Wolstenholme and C.M. O’Connor eds.), Little, Brown, Boston, pp. 58–77.Google Scholar
  20. Kilbourne, E. D., 1963, in: Infections primarily of the respiratory tract, Preventive Medicine and Public Health (W. G. Smillie and E. D. Kilbourne, eds.), Macmillan, New York, p. 192.Google Scholar
  21. Kilbourne, E. D., 1975, The Influenza Viruses and Influenza ,Academic Press, New York.Google Scholar
  22. Kilbourne, E. D., 1977, Influenza pandemics in perspective, J.A.M.A. 237:1225–1228.PubMedCrossRefGoogle Scholar
  23. Kilbourne, E. D., and Loge, J. P., 1950, Influenza A prime: A clinical study of an epidemic caused by a new strain of virus, Ann. Intern. Med 33:371–379.PubMedGoogle Scholar
  24. Kilbourne, E. D., Anderson, H. C., and Horsfall, F. L., Jr., 1951, Concurrent infection with influenza A and B viruses in a single epidemic, J. Immunol. 67:547–558.PubMedGoogle Scholar
  25. Krilov, L. R., and Swenson, P., 1985, Acute parotitis associated with influenza A infection,/. Infect. Dis. 152:853.CrossRefGoogle Scholar
  26. Kung, H. C., Jen, K. F., Yuan, W. C., et al., 1978, Influenza in 1977: recurrence of influenzavirus A subtype H1N1, Bull. WHO 56:913–918.PubMedGoogle Scholar
  27. Langmuir, A. D., 1961, Epidemiology of asian influenza, Am. Rev. Respir. Dis. 83:2–14.PubMedGoogle Scholar
  28. Louria, D. B., Blumenfeld, H. L., Ellis, J. T., et al., 1959, Studies on influenza in the pandemic of 1957–58. II. Pulmonary complications of influenza, J. Clin. Invest. 38:213–265.PubMedCrossRefGoogle Scholar
  29. Masurel, N., and Heijtink, R. A., 1983, Recycling of H1N1 influenza A virus in man-a haemagglutinin antibody study, J. Hyg. 90:307–402.CrossRefGoogle Scholar
  30. Masurel, N., and Marine, W. M., 1973, Recycling of Asian and Hong Kong influenza A virus hemagglutinins in man, Am. J. Epidemiol. 97:44–49.PubMedGoogle Scholar
  31. Meiklejohn, G., and Bruyn, H. B., 1949, Influenza in California during 1947 and 1948, Am. J. Public Health 39:44–49.CrossRefGoogle Scholar
  32. Morton, G, 1973, The pandemic influenza of 1918, Can. Nurse 69:25–27.PubMedGoogle Scholar
  33. Nakajima, K., Nakajima, S., Shortridge, K. F., et al., 1982, Further genetic evidence of maintenance of early Hong Kong-like influenza A(H3N2) strains in swine until 1976, Virology 116:562–572.PubMedCrossRefGoogle Scholar
  34. Ottis, K., Sidoli, L., Bachmann, P. A., et al., 1982, Human influenza A viruses in Pigs: Isolation of a H3N2 strain antigenically related to A/England/42/72 and evidence for continuous circulation of human viruses in the pig population, Arch. Virol. 73:103–108.PubMedCrossRefGoogle Scholar
  35. Patterson, K. D., and Pyle, G. F., 1983, The diffusion of influenza in sub-Saharan Africa during the 1918–1919 pandemic, Soc. Sci. Med. 17:1299–1307.PubMedCrossRefGoogle Scholar
  36. Phillips, H., 1978, Black October: Cape Town and the Spanish influenza epidemic of 1918, in: Conference on the Economics of Health Care in Southern Africa ,University of Capetown, Capetown, S. A., paper #36.Google Scholar
  37. Pool, D. I., 1973, The effects of the 1918 pandemics of influenza on the Maori population of New Zealand, Bull. Hist. Med. 47:273–281.PubMedGoogle Scholar
  38. Rasmussen, A. F., Jr., Stoker, J. C., and Sinadel, J. E., 1948, The army experience with influenza 19461947. II. Laboratory aspects. Am. J. Hyg. 47:142–149.PubMedGoogle Scholar
  39. Rekart, M., Rupnik, K., Cesario, T. C., et al., 1982, Prevalence of hemagglutination inhibition antibody to current strains of the H3N2 and H1N1 subtypes of influenza A virus in sera collected from the elderly in 1976, Am. J. Epidemiol. 115:587–597.PubMedGoogle Scholar
  40. Sartwell, P. E., and Long, A. P., 1948, The Army experience with influenza, 1946–1947. I. Epidemiological aspects, Am. J. Hyg. 47:135–141.PubMedGoogle Scholar
  41. Schild, G., 1978, An ’old’ flu virus returns, New Scientist 79:949–950.Google Scholar
  42. Schulman, J. L., and Kilbourne, E. D., 1969, Independent variation in nature of the hemagglutinin and neuraminidase antigens of influenza virus: Distinctiveness of the hemagglutinin antigen of Hong Kong/68 virus, Proc. Natl. Acad. Sci. 63:326–333.PubMedCrossRefGoogle Scholar
  43. Semple, A. B., 1951, Epidemiology of the influenza epidemic in Liverpool in 1950–51, Proc. R. Soc. Med. 44:794–796.Google Scholar
  44. Shope, R. E., 1958, Influenza. History, epidemiology, and speculation. (The R. E. Dyer Lecture), Public Health Rep. 73:165–178.PubMedCrossRefGoogle Scholar
  45. Smith, W., Andrewes, C. H., and Laidlaw, P. P., 1933, A virus obtained from influenza patients, Lancet 2:66–68.CrossRefGoogle Scholar
  46. Starr, I., 1976, Influenza in 1918, Ann. Intern. Med. 85:516–518.PubMedGoogle Scholar
  47. Thompson, T., 1852, Annuals of Influenza or Epidemic Catarrhal Fever in Great Britain from 1510 to 1837. Sydenham Society, London.Google Scholar

Copyright information

© Edwin D. Kilbourne, M.D. 1987

Authors and Affiliations

  • Edwin D. Kilbourne
    • 1
  1. 1.Mount Sinai School of MedicineCity University of New YorkNew YorkUSA

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