Physiological Responses of Intestinal CTP: Phosphocholine Cytidylyltransferase and its Interaction with Lipophilic Drugs

  • Charles M. MansbachII
  • Anne Arnold
Part of the NATO ASI Series book series (NSSA, volume 116)


Because of the importance of phosphatidylcholine (PC) to biologic membrances, its synthesis has been studied extensively in many different cell systems. De novo PC synthesis is composed of a series of 3 enzymes in which choline is phosphorylated, condensed with CTP and finally transferred to diacylglycerol. It is the second step, mediated by CTP: phosphocholine cytidylyltransferase (PCT) (EC, which has been proposed by a number of workers to be rate limiting in this pathway (1–4). This enzyme has been found in both cytosol and microsomes (5). It has been proposed that the microsomal form of the enzyme provides the substrate for the terminal step in the pathway of PC synthesis while the cytosolic form acts as a reservoir (1,6).


Bile Duct Lipophilic Drug Cytosolic Enzyme Intestinal Enzyme Bile Fistula 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Charles M. MansbachII
    • 1
  • Anne Arnold
    • 1
  1. 1.Duke University Medical CenterDurhamUSA

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